哌拉西林他唑巴坦联合莫西沙星对老年肺炎患者中应用价值分析

Application Value of Piperacillin Tazobactam Combined with Moxifloxacin in Elderly Patients with Pneumonia

目的研究哌拉西林他唑巴坦结合莫西沙星对老年肺炎患者的临床疗效价值。方法择2021年2月-2022年3月本院确诊老年肺炎患者50例,按随机数字法分观察组和对照组各25例;对照组滴注哌拉西林钠他唑巴坦钠注射剂,观察组在此之上静脉滴注莫西沙星注射液,比较治疗前后两组的疗效判定指标、血常规指标、CT影像学异常情况及炎症因子水平。结果治疗后观察组临床总有效率高于对照组(P<0.05);治疗后两组白细胞(WBC)和中性粒细胞比率(NE%)均显著下降,CT影像学异常均明显好转,且观察组WBC、NE%明显低于对照组,且观察组CT影像学异常情况明显少于对照组(P<0.05);治疗后两组降钙素原(PCT)、C-反应蛋白(CRP)及白细胞介素-6(IL-6)均显著降低,且观察组PCT、CRP及IL-6明显低于对照组(P<0.05)。结论哌拉西林他唑巴坦结合莫西沙星对老年肺炎患者有很好的应用价值,可改良肺功能,减少炎症因子,值得广泛应用。

Objective To study the clinical efficacy of piperacillin tazobactam combined with moxifloxacin in elderly patients with pneumonia.Methods From February 2021 to March 2022,50 elderly patients with pneumonia in our hospital were selected and divided into observation group and control group by random number method,with 25 cases in each group.The control group was given piperacillin sodium and tazobactam sodium injection,while the observation group was given moxifloxacin injection.The efficacy evaluation indexes,blood routine indexes,CT imaging abnormalities and inflammatory factors levels were compared between the two groups before and after treatment.Results After treatment,the total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the ratio of white blood cell(WBC)and neutrophil(NE%)in the two groups were significantly decreased,and the abnormality of CT imaging was significantly improved,and the WBC and NE%in the observation group were significantly lower than those in the control group,and the abnormality of CT imaging in the observation group was significantly less than that in the control group(P<0.05).After treatment,procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)in the two groups were significantly decreased,and the PCT,CRP and IL-6 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Piperacillin tazobactam combined with moxifloxacin has good application value in elderly patients with pneumonia,which can improve lung function and reduce inflammatory factors.It is worthy of wide application.