不可逆电穿孔治疗肝门区域肿瘤的优势

Advantages of irreversible electroporation for the ablation of hepatic hilar tumors

肝脏肿瘤的局部治疗方式有手术切除、介入术、热消融术和冷冻消融术等,这些治疗手段在临床中能治疗大多数肝脏肿瘤。然而,由于肝门区域肿瘤的位置毗邻血管、神经和胆道等重要结构,肝门区域肿瘤的切除率或者毁损率、肿瘤周围管道结构的保护、治疗误损伤、肝硬化患者残肝的保护、降低并发症等各方面要达到良好的平衡,传统局部治疗方式处理肝门区域肿瘤存在一定的局限性。不可逆电穿孔(irreversible electroporation,IRE)消融术由于其引导细胞凋亡,保护血管、胆管等重要结构不受热损伤的特点,因此在治疗肝门区域特殊部位肿瘤中具有更加明显的优势。本文主要介绍与传统热消融术相比,IRE消融术治疗肝门区域特殊部位肿瘤的优势。

The local treatments of liver tumors included surgical procedures,interventional procedures,thermal ablation,cryoablation treatment and other treatments,which can cure most liver tumors.But for the hepatic hilar tumors,Due to the special part of the lesion location adjacent to blood vessels,nerve,biliary and other important structure,the tumor resection rate or damage rate,tumor around the protection of pipe structure,treatment injury,cirrhosis patients with residual liver protection,complications reduction must achieve a good balance.However,the traditional local treatmenst have limitations.Due to the advantages of irreversible electroporation(IRE)ablation technology,such as guidance of cell apoptosis,protect blood vessels,bile duct and other important structures,the application of IRE technology for the ablation of tumors in the special parts of the hepatic portal region has more obvious effectiveness and safety advantages.This review mainly introduces the principle,effectiveness and safety of IRE ablation in special parts of hepatic portal region compared with traditional thermal ablation.