长链非编码RNA在糖尿病溃疡中的作用机制

The mechanisms of long chain non-coding RNA in diabetic ulcer

糖尿病溃疡会影响患者的生活质量,给个人和医疗系统带来巨大的社会和经济负担。虽然对糖尿病溃疡的治疗方法已有大量探索,但仍无有效的治疗策略;因此,进一步探索替代方案很有必要。糖尿病溃疡的分子机制仍不完全清楚。长链非编码RNA(long chain non-coding RNA, lnc RNA)是长度超过200个核苷酸(nt)并且具有有限或没有蛋白质编码能力的RNA分子。过去10年中,lncRNA已被证明参与多种生物学过程,并在各种疾病的发病机制中发挥重要作用。本文总结了最近关于lncRNAs在糖尿病溃疡中的研究进展,主要关注它们在糖尿病溃疡微血管损伤、炎症、氧化应激等中的调节作用,并总结出相关潜在靶点,有望推动今后lncRNA作为调控糖尿病溃疡的生物标志物和治疗靶点,从而提供防治糖尿病溃疡的新思路。

Diabetic ulcer affects the patients’quality of life and brings huge social and economic burden to individuals and the health system.Although the treatment for diabetes ulcer has been explored,there is still no effective treatment strategy;therefore,it is necessary to further explore alternatives.The molecular mechanism of diabetes ulcer is still not completely clear.Long chain non-coding RNA(lncRNA)is an RNA molecule with a length of more than 200 nucleotides(nt)and with limited or no protein coding ability.In the past 10 years,lncRNA has been proved to participate in a variety of biological processes and play an important role in the pathogenesis of various diseases.This article summarizes the recent research progress of lncRNAs in diabetes ulcers,focusing on their regulatory role in microvascular injury,inflammation,oxidative stress,etc.in diabetes ulcers;and summarizes relevant potential targets,which is expected to promote lncRNAs as biomarkers and therapeutic targets for regulating diabetes ulcers in the future,so as to provide new ideas for the prevention and treatment of diabetes ulcers.