胶原性胃炎的研究进展

Research progress on collagenous gastritis

胶原性胃炎(CG)是一种少见的疾病,主要特征为胃黏膜上皮下出现厚度>10μm的胶原沉积带,固有层内炎细胞浸润。CG发病机制尚未明确,可能与自身免疫、炎症、药物等多种因素相关,其临床表现复杂多变,为慢性复发迁延过程,分为儿童首发及成人首发两组临床症候群。目前无标准治疗方案,已报道的治疗方案包括低过敏饮食、抑制胃液分泌、消化道黏膜保护剂、铁剂、皮质类固醇激素、氨基水杨酸制剂、免疫抑制剂等,治疗效果及随访结果不完全一致。该文就目前国内外CG的研究进展作一综述。

Collagenous gastritis(CG)is a rare disease characterized by a zone of collagen deposits of>10μm in thickness under the gastric mucosal epithelium with infl ammatory cell infiltration in the lamina propria.The pathogenesis of CG is still unclear,which may be related to many factors,such as autoimmunity,infl ammation and drugs,etc.Clinical manifestations of CG are complex and diverse with a chronic recurrence and prolonged process,which can be divided into child-and adult-onset groups of clinical symptoms.At present,there is no standard treatment for CG.The following therapeutic regimens have been employed including hypoallergenic diet,inhibition of gastric juice secretion,gastrointestinal mucosal protective agent,oral iron agent,glucocorticoid,5-aminosalicylicacid and immunosuppressive agents.However,clinical efficacy and follow-up outcomes are not completely consistent.In this article,research progresses on CG at home and abroad were reviewed.