摘要
富亮氨酸胶质瘤失活1蛋白(LGI1)抗体相关脑炎属于自身免疫性疾病,临床表现复杂多样,容易被误诊。该文报道1例LGI1抗体相关脑炎的74岁男性患者,其以意识丧失、四肢抽搐为首发症状,1年内发作2次,MRI检查未见明显异常信号,完善自身免疫性脑炎抗体检验,结果显示LGI1抗体血清及脑脊液抗体均(+)。确诊后予糖皮质激素及免疫治疗,患者症状明显好转。
Leucine-rich glioma inactivated 1(LGI1)antibody-associated encephalitis is an autoimmune disease with complex and diverse clinical manifestations and is prone to misdiagnosis.In this article,one case of LGI1 antibody-associated encephalitis was reported.This patient presented with loss of consciousness and limb twitches as the first symptoms,which occured twice within a year.No obvious abnormal signal was found by MRI.Autoimmune encephalitis antibody test showed that both serum and cerebrospinal fluid samples were positive for LGI1 antibody,which confirmed the diagnosis.Relevant symptoms were significantly improved after glucocorticoid use and immunotherapy.
作者
刘曈
夏丽萍
贾玉勤
Liu Tong;Xia Liping;Jia Yuqin(The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《新医学》
CAS
2023年第4期294-297,共4页
Journal of New Medicine
关键词
富亮氨酸胶质瘤失活1蛋白
自身免疫性脑炎
临床表现
复发
Leucine-rich glioma inactivation 1 protein
Autoimmune encephalitis
Clinical manifestation
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