C激酶底物蛋白、人类表皮生长因子受体2与胃癌患者临床病理特征的相关性

Correlation between C-kinase substrate,human epidermal growth factor receptor 2 and pathological features of gastric cancer

目的探讨豆蔻酰化富丙氨酸C激酶底物蛋白(MARCKS)和人类表皮生长因子受体2(HER2)与胃癌患者临床病理特征的相关性。方法2018年3月到2021年3月,选择我院收治的60例胃癌患者作为观察组,选择同期60例良性胃部肿瘤患者作为对照组,应用免疫组化法检测两组受检者MARCKS和HER2的表达水平,并分析观察组织中MARCKS、HER2蛋白表达与胃癌患者临床病理特征的关系。结果观察组患者MARCKS、HER2阳性率均明显高于对照组(P<0.05);观察组中,MARCKS、HER2阳性与阴性患者性别、年龄、肿瘤大小比较无明显差异(P>0.05),而TNM分期、淋巴结转移、组织分化程度差异有统计学意义(P<0.05);Spearman相关分析显示,TNM分期、淋巴结转移、组织分化程度与MARCKS和HER2表达呈正相关(P<0.05)。结论胃癌组织中,MARCKS、HER2蛋白表达升高,且MARCKS和HER2蛋白表达水平与胃癌患者的TNM分期、淋巴结转移和组织分化程度呈正相关,可为胃癌的临床诊断和预后评估提供参考价值。

Objective To investigate the correlation between myristoylated alanine-rich C kinase substrate(MARCKS),human epidermal growth factor receptor 2(HER2)and pathological features of patients with gastric cancer.Methods A total of 60 patients with gastric cancer admitted to our hospital from March 2018 to March 2021 were selected as the study object,as the gastric cancer group,and 60 patients with benign gastric tumors were selected as the control group.Immunohistochemical method was used to detect the expression levels of MARCKS and HER2 in the two groups.The relationship between MARCKS and HER2 proteins in gastric cancer tissues and clinicopathologic features of patients with gastric cancer was analyzed.Results The expression levels of MARCKS and HER2 showed that the positive rates of MARCKS and HER2 in the gastric cancer group were significantly higher than those in the control group(P<0.05).In gastric cancer group,there were no significant differences in gender,age and tumor size between MARCKS and HER2-positive and negative patients(P>0.05).However,there were statistically significant in TNM staging,lymph node metastasis and tissue differentiation.Spearman correlation analysis showed that TNM stage,lymph node metastasis and degree of tissue differentiation were positively correlated with MARCKS and HER2(P<0.05).Conclusion In gastric cancer tissues,MARCKS and HER2 protein expressions are elevated,and the expression levels of MARCKS and HER2 protein are positively correlated with TNM staging,lymph node metastasis and tissue differentiation degree of patients with gastric cancer,which can provide reference value for clinical diagnosis and prognosis evaluation of gastric cancer.