摘要
Microbial production of value-added products is a promising alternative to plant-and chemical-based routes[1].However,only few of interested chemicals are producing at bulk scale with microbial cell factories(eg.artemisinic acid)while most are staying at bench level.To enable the microbes toward efficient bioproduction,extensive endeavors have been expended on enzyme exploration and pathway decoration,leaving the role of cofactors,especially the rare cofactors like SAM,FMN(H_(2))and FAD(H_(2)),largely unconsidered[2,3].
基金
This work was supported by supported by Natural Science Foundation of Shaanxi Province(2020JM-177)
Chinese Universities Scientific Fund(2452018314).
