摘要
Natural products are one of the major sources of small-molecule pharmaceutical drugs[1,2].However,discovery of novel natural products to expand the pool of potential drug candidates is becoming more and more challenging.Most of the traditional molecule discovery methods are based on direct separation of natural product from its natural hosts or homology search of biosynthetic pathways.However,there are currently two main obstacles in discovery of natural products from their native hosts:1)the difficulty in cultivation of the native hosts under laboratory conditions,2)no or not enough production of target natural products due to the silence of the biosynthetic pathway genes in the native hosts.Therefore,novel platforms are required for efficient discovery of new natural products.
基金
This work was supported by Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(2060302).
