Splenectomy may facilitate systemic therapy for advanced hepatocellular carcinoma with hypersplenism

Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related deaths globally and is widely considered to be a serious threat to human health.In clinical settings,more than 70%of HCCs are unresectable at initial diagnosis and are therefore treated with palliative rather than curative treatment,which severely reduces the overall survival of HCC patients(1).