EB病毒阳性的胃癌与伴有淋巴样间质的胃癌——诊断及分子检测进展

Advances in diagnosis and molecular detection of EBV-positive gastric cancer and gastric cancer with lymphoid stroma

EB病毒阳性的胃癌与伴有淋巴样间质的胃癌均属于胃癌特殊病理亚型。其组织学形态、免疫学与遗传学特征存在部分重叠,却不完全相同。因此,这一组肿瘤不仅引起病理医师诊断上的困惑,同时也不利于临床治疗及后续研究。本文对这两种肿瘤以及与之相近诊断术语作详细介绍及对比,探讨其临床病理特征、遗传学改变、分子检测及治疗进展,并归纳总结现存争议及未来研究方向。

Epstein-Barr virus-positive gastric cancer,as well as gastric cancer with lymphoid stroma,are the special pathological subtypes of gastric cancer.The histological morphology,immunological and genetic characteristics between two subtypes are overlapped to some extent,however,they are not identical.Therefore,there were not only the confusion in the diagnosis for pathologists but also perplexity in clinical treatment and following research caused by two subtypes of gastric cancer.In this article,the two cancers and other similar diagnostic terms were introduced and compared in detail.The clinicopathological features,genetic variation,molecular detection,and treatment progress were summarized combined with both current controversies and future directions of research.