以STING为代表的天然免疫信号通路在银屑病中的研究进展

Research progress on innate immune signaling pathways represented by STING in psoriasis

银屑病是一种由多因素引起的免疫紊乱疾病。其发病机制复杂,主要以白细胞介素-23/辅助性T细胞17(IL-23/Th17)信号轴为核心,其他关键途径还包括抗病毒信号通路、促炎因子和趋化因子表达以及抗原处理和呈递过程等。在银屑病的皮损环境中存在着各种自身抗原或病原体,其可通过激活模式识别受体[如干扰素基因刺激因子(STING)、Toll样受体(TLR)、维甲酸诱导基因1蛋白(RIG1)等]进而活化下游转录因子[核转录因子κB(NF-κB)、干扰素调节因子(IRF)等]而激活促炎信号,从而促进银屑病的发病进程。本文综述了天然免疫信号通路中的不同模式识别受体在银屑病的发生发展的作用机制,为潜在的治疗靶点做一总结。

Psoriasis regards as a type of complicated immune disorder with versatile external and internal pathological triggers,of which mechanism remains unclear.Currently,the well-known dominant pathway is IL-23/Th17 axis,along with other participated compartments,such as antiviral patterns,pro-/pre-inflammatory cytokines,and molecules involved in antigen presentation.Amongst all,numerous autoantigens or pathogens inevitably invade and exist in the psoriatic lesion environment.They trigger PRR(pattern recognition receptors),such as STING,TLR,RIG1 and according downstream transcription factors(e.g.NF-κB and IRF),which eventually accelerate psoriasis progress.This review summarized the mechanisms of action of different pattern recognition receptors in innate immune signaling pathways in psoriasis progress for further development of therapeutics.