Nicotine Addiction Models and Evaluation of Animal Behavior

Nicotine is one of the most widely concerning components of cigarette smoke.Long-term intake of nicotine can lead to nicotine dependence that affects higher brain functions,which may involve anxiety,learning and memory impairments,and abnormal decision-making.To facilitate analyzing the molecular mechanisms of nicotine dependence,it is common to establish rodent nicotine dependence models to better understand the physiological changes.This paper summarizes and evaluates the application of animal behavior evaluation experiments in nicotine-dependent animal models,in order to provide a reliable reference for researchers to establish rodent nicotine-dependent models for evaluation.