牛膝治疗糖尿病周围神经病变的作用机制

The Mechanisms of Achyranthes Bidentata Blume in Treating Diabetic Peripheral Neuropathy

为探讨中药牛膝治疗糖尿病周围神经病变的机制,分别采用网络药理学及分子对接,对牛膝治疗糖尿病周围神经病变的活性成分进行预测。研究结果表明:网络药理学分析,筛选得到牛膝对糖尿病周围神经病变治疗有效成分11种,关键靶点主要为AKT1、IL-6、CASP3和VEGFA。功能富集分析结果表明,牛膝可能通过协同调节HIF-1、MAPK、Fox0等多种生物途径来治疗糖尿病周围神经病变。分子对接结果表明,红厚壳内酯是一种具有良好分子对接性能的先导化合物。本研究阐明了牛膝治疗糖尿病周围神经病变的活性成分和作用机制,为寻找治疗糖尿病周围神经病变的先导化合物和新药研发提供了理论依据。

To systematically investigate the mechanisms of Achyranthes Bidentata Blume in treating diabetic peripheral neuropathy.Methods:In this study,network pharmacology,molecular docking analysis were used to predict the active components of Achyranthes Bidentata Blume in the treatment of DPN.Results:The network analysis showed that there were 17 active components of Achyranthes Bidentata Blume in treating DPN.And the key targets were AKT1 IL 6,CAPSP3 and VEGFA.The functional enrichment analysis indicated that Achyranthes Bidentata Blume may treat DPN by synergistically regulating many biological pathways,such as HIF 1,MAPK and Fox0 signaling pathway,etc.In addition,the results of molecular docking showed that Inophyllum E might be a promising leading compound with good molecular docking performance.Conclusions:The active components and mechanism of action of diabetic peripheral neuropathy were fully elucidated in this study,and laid a foundation for finding lead compounds of DPN and developing new drugs for the treatment of DPN.