妊娠合并骨髓增生异常综合征一例

Pregnancy Complicated by Myelodysplastic Syndrome:A Case Report

骨髓增生异常综合征(myelodysplastic syndrome,MDS)是一组未被充分认识的血液学克隆恶性肿瘤,具有不同的白血病转化倾向。MDS可表现为不同程度的贫血、中性粒细胞减少和血小板减少。妊娠合并MDS病例罕见,临床上相关研究较少,目前国内外对其诊断和治疗还没有规范的指南。回顾性分析兰州大学第一医院1例妊娠合并MDS的患者,在血液科和产科共同努力下,给予促肺成熟、纠正贫血及升血小板治疗并成功分娩一健康婴儿的病例资料,旨在加强对妊娠合并MDS患者妊娠前、妊娠期及围产期管理的认识,为临床工作提供参考。

Myelodysplastic syndrome(MDS)is an under-recognized group of hematologic clone malignancies with different leukemia transformation tendencies.MDS may present with varying degrees of anemia,neutropenia and thrombocytopenia.The cases of pregnant patients with MDS are rare,and there are few related clinical studies.At present,there are no standardized guidelines for the diagnosis and treatment of MDS at home and abroad.A retrospective analysis was made of the case data of a pregnant patient with MDS in the First Hospital of Lanzhou University,who was given lung maturation promotion,anemia correction and platelet enhancement therapy under the joint efforts of the department of hematology and obstetrics,and delivered a healthy baby successfully.The purpose of this study was to strengthen the understanding of the management of pregnant patients with MDS before pregnancy,pregnancy and peripartum,and to provide reference for clinical work.