宫颈毛玻璃样细胞癌一例并文献复习

Glassy Cell Cervical Carcinoma:A Case Report and Literature Review

宫颈毛玻璃样细胞癌(glassy cell cervical carcinoma,GCCC)是一种罕见的宫颈恶性肿瘤,属于腺鳞癌的低分化亚型,国内外相关报道较少。由于其罕见性及特殊性,目前国内外尚无相应的诊疗规范。报道1例43岁的ⅡB期GCCC患者的诊治过程,该患者经同步放化疗后行腹腔镜下全子宫+双附件切除手术,术后给予了3个疗程的紫杉醇联合顺铂的辅助化疗,然而短期内出现全身多处复发转移,在更换多个化疗方案后治疗效果欠佳,最终失访。结合该病例并复习国内外相关文献,旨在提高对该病的认识和诊疗水平,为后续研究提供更多参考。

Glassy cell cervical carcinoma(GCCC)is a very rare form of cervical carcinoma,which belongs to the lowdifferentiated subtype of adenosquamous carcinoma,and the related reports at home and abroad are few.Due to its rarity and particularity,there are currently no relevant guidelines for diagnosis and treatment of this disease.This article reports the diagnosis and treatment process of a 43-year-old patient with stageⅡB GCCC who underwent laparoscopic total hysterectomy combined with bilateral adnexectomy after concurrent chemoradiotherapy,and was also given 3 courses of adjuvant chemotherapy with paclitaxel and cisplatin.However,in a short period of time,there have been multiple metastases throughout the body.The patient responded poorly to multiple chemotherapy regimens and was eventually lost.This article reviews the relevant literature both domestic and abroad,aiming to improve the understanding,diagnosis and treatment of the disease,and provide more reference for diagnosis and treatment for follow-up study of this disease.