宫颈高级别鳞状上皮内病变累及子宫内膜、卵巢一例并文献复习

Cervical High-Grade Squamous Intraepithelial Lesions Involving the Endometrium and Ovary:A Case Report and Literature Review

宫颈鳞状细胞癌以浅表扩散的方式累及子宫内膜表面较为罕见,目前仍缺乏针对性的临床诊疗指导。报道1例60岁女性,因绝经后异常阴道流液就诊于我院,人乳头瘤病毒16阳性,后行腹腔镜全子宫+双侧附件切除术,术后病理结果示:宫颈高级别鳞状上皮内病变累及腺体,广泛浅表蔓延至子宫内膜,并累及右侧卵巢浆膜面,且3处病灶呈现p16及Ki-67的一致性高表达。对既往文献报道及本病例特点进行归纳总结,以期为疾病的早期诊治提供依据,改善临床预后。

Cervical squamous cell carcinoma that spreads superficially to the inner surface of the endometrium has been rarely reported.There is still lack of clinical guidance for this disease entity.In this paper,we report a case of a 60-year-old woman who presented to our hospital with"abnormal postmenopausal vaginal discharge"and was positive for human papillomavirus 16,followed by laparoscopic total hysterectomy and bilateral salpingo-oophorectomy.Postoperative pathological findings showed that the high-grade squamous intraepithelial lesions of the cervix involved the glands and spread widely superficially to the endometrium and involved the plasma surface of the right ovary.All the lesions showed consistent high expression of p16 and Ki-67.We summarize the previous reports and the characteristics of this case in order to provide evidence for early diagnosis and treatment of the disease and improve clinical prognosis.