中医药治疗骨质疏松症研究进展

Research Progress of TCM in Treating Osteoporosis

随着年龄的增长,骨质疏松症的发病率逐年升高,笔者通过检索中医药治疗骨质疏松症的相关文献发现,肾精亏损是本病的根本,肝疏泄功能不足、脾运化功能异常是本病发生的重要原因,而血瘀是骨质疏松症发展的必经阶段。现代研究从肾、肝、脾及瘀的角度着手治疗骨质疏松症能取得很好的疗效,其机制为激活或抑制骨质疏松症相关的PI3k/Akt、MAPK、Wnt/β-catenin、NF-κB和OPG/RANKL/RANK信号通路,从而维持体内的骨平衡。

The incidence of osteoporosis increases with age.By reviewing relevant literature of TCM in treating osteoporosis,it is found that Kidney-essence is the root cause of the disease,malfunction of Liver in draining and dredging,as well as disorder of Spleen in transporting and transforming are important causes of the disease,and blood stasis is a necessary stage in the development of the disease.Modern research has shown that the treatment of osteoporosis from the perspectives of Kidney,Liver,Spleen and blood stasis can achieve good results,which mechanism is to activate or inhibit osteoporosis-related signaling pathways of PI3K/Akt,MAPK,Wnt/B-catenin,NF-κB and OPG/RANKL/RANK to maintain bone homeostasis within the body.