基于数据挖掘研究高脂血症性急性胰腺炎方药规律

Study on the Prescription Law of Hyperlipidemic Acute Pancreatitis Based on Data Mining

目的搜集文献建立高脂血症性急性胰腺炎中医方药数据库,运用数据挖掘技术探寻治疗高脂血症性急性胰腺炎(hyperlipidemic acute pancreatitis,HLAP)的核心方药及其配伍规律。方法对建库至今所有期刊及文献中所记载的HLAP方剂进行筛选,建立方药数据库,采用频率分析、关联规则分析、复杂网络分析和聚类分析对用药的核心和常用配伍进行分析。结果生大黄、芒硝、柴胡、厚朴、黄芩、枳实是治疗HLAP的常用中药;用药四气以寒、温为主,五味以辛、苦为主,药物归经以脾、肝、胃为主。二项、三项常用药对主要是由生大黄、芒硝、厚朴、黄芩、柴胡交叉配对形成的。系统聚类分析高频药物得出2组药物组合;复杂网络核心处方主要由大柴胡汤加减组成。结论HLAP中医治疗的核心处方为方剂大柴胡汤加减,常配伍芒硝、赤芍、木香、延胡索、桃仁等,为中医临床治疗HLAP提供研究思路与选药方向。

Objective To collect literature,establish a hyperlipidemic acute pancreatitis(HLAP)traditional Chinese medicine database,and use data mining techniques to explore the core prescriptions and compatibility rules for the treatment of HLAP.Methods Prescriptions recorded in all journals and literature since the establishment of the database were sifted and the basic and universal compatibility of traditional Chinese medicine was analyzed using frequency analysis,association rule analysis,complex network analysis,and cluster analysis.Results In the treatment of HLAP,Dahuang(Rhei Radix Et Rhizoma),Mangxiao(Natrii Sulfas),Chaihu(Bupleuri Radix),Houpo(Magnoliae Officinalis Cortex),Huangqin(Scutellariae Radix),Zhishi(Aurantii Fructus Immaturus)are often used.The four Qi of medicine are mainly cold and warm,and the five flavors are mainly pungent and bitter.The meridians of drugs are mainly spleen,liver and stomach.The two and three commonly used drug pairs are mainly formed by cross pairing of Dahuang(Rhei Radix Et Rhizoma),Mangxiao(Natrii Sulfas),Houpo(Magnoliae Officinalis Cortex),Huangqin(Scutellariae Radix),Chaihu(Bupleuri Radix),Systematic cluster analysis results in two groups of combinations.The main recipe for complex net mainly consists of adding and subtracting Dachaihu Decoction(大柴胡汤).Conclusion The main recipe of HLAP traditional Chinese medicine treatment is adding and subtracting Dachaihu Decoction,which is often combined with Mangxiao(Natrii Sulfas),Chishao(Paeoniae Radix Rubra),Muxiang(Aucklandiae Radix),Yanhusuo(Corydalis Rhizoma),Taoren(Persicae Semen),this paper provides research ideas and drug selection direction for the clinical treatment of HLAP in traditional Chinese medicine.