复方伤痛胶囊辅助经皮椎体成形术治疗骨质疏松性胸腰椎压缩性骨折临床研究

Clinical Study on Compound Shangtong Capsules Assisting Percutaneous Vertebroplasty for Osteoporotic Thoracolumbar Vertebral Compression Fractures

目的:观察复方伤痛胶囊辅助经皮椎体成形术(PVP)治疗骨质疏松性胸腰椎压缩性骨折(OTCF)的临床疗效。方法:选取150例OTCF患者,采用随机数字表法分为对照组和观察组,每组75例。2组均行PVP治疗,对照组术后给予止痛、吸氧、卧床制动、抗感染、抗骨质疏松、康复训练等方案治疗,观察组在对照组基础上加用复方伤痛胶囊治疗。比较2组临床疗效、并发症发生率,以及术前与术后3个月椎体前缘高度、椎体楔变角、椎体后凸Cobb角和骨密度。结果:术后3个月,观察组临床疗效总有效率97.33%,高于对照组89.33%(P<0.05)。术后3个月,2组椎体前缘高度均较术前增加(P<0.05),椎体楔变角、后凸Cobb角均较术前减小(P<0.05);观察组椎体前缘高度高于对照组(P<0.05),椎体楔变角、后凸Cobb角均小于对照组(P<0.05);2组L_(2~4)椎体、左股骨颈骨密度均较术前增加(P<0.05);观察组L_(2~4)椎体、左股骨颈骨密度均大于对照组(P<0.05)。术后3个月内,观察组并发症发生率8.00%,略高于对照组5.33%,但2组比较,差异无统计学意义(P>0.05)。结论:复方伤痛胶囊辅助PVP治疗OTCF可提高临床疗效,增加骨密度,促进患者伤椎康复。

Objective: To observe the clinical effect of Compound Shangtong Capsules assisting percutaneous vertebroplasty(PVP) on osteoporotic thoracolumbar vertebral compression fractures(OTCF).Methods: A total of 150 patients with OTCF were selected and divided into the control group and the observation group according to the random number table method, with 75 cases in each group. Both groups were treated by PVP, the control group was given postoperative treatments, including relieving pain, oxygen inhalation, bedridden immobilization, anti-infection, anti-osteoporosis and rehabilitative exercise,and the observation group was additionally treated with Compound Shangtong Capsules based on the treatment of the control group. The clinical effects,incidence of complications as well as the anterior vertebral height,wedging angle of vertebrae,Cobb angle of kyphosis of vertebrae and bone density before PVP and after 3 months of PVP were compared between the two groups. Results: After 3 months of operation,the total effective rate of clinical effect was 97.33% in the observation group,higher than that of 89.33% in the control group(P<0.05). After 3 months of operation,the anterior vertebral height in both groups were increased when compared with that before PVP(P<0.05), the wedging angle of vertebrae and Cobb angle of kyphosis were reduced when compared with those before PVP(P<0.05);the anterior vertebral height in the observation group was higher than that in the control group(P<0.05),the wedging angle of vertebral and Cobb angle of kyphosis were smaller than those in the control group(P<0.05);the values of L_(2~4) vertebrae and density of left femoral neck bone were increased when compared with those before treatment(P<0.05);the values of L_(2~4) vertebrae and density of left femoral neck bone in the observation group were bigger than those in the control group(P<0.05). Within 3 months after operation,the incidence of complications was 8.00% in the observation group,slightly higher than that of5.33% in the control group,there being no significance in the difference(P>0.05). Conclusion:Compound Shangtong Capsules assisting PVP for OTCF can enhance the clinical effect, increase the bone density,and promote the recovery of injured vertebrae of patients.