全球1999—2021年间关于胰岛素瘤的文献计量分析

Bibliometric analysis of global literature on insulinoma from 1999 to 2021

背景与目的:胰岛素瘤是胰腺最常见的功能性内分泌肿瘤。然而很少有关于胰岛素瘤的文献计量学研究。因此本研究将通过文献计量分析这一方法描述近20年来胰岛素瘤领域研究的热点和趋势。方法:通过Web of Science核心数据库(WoSCC)检索1999—2021年间与胰岛素瘤相关的出版文献,并以纯文本格式导入VOSviewer和CiteSpace软件。数据使用文献计量方法进行处理,对作者、国家、机构、高被引文献、共被引、关键词和参考文献进行文献可视化分析。结果:共检索到3863篇文献,包括19310位作者,3268个组织,83个国家/地区和1005种期刊,文献共引用了来自7494种期刊合计55619位作者的85078篇文章。其中,相关研究主要在美国进行,Lernmark A是最高产的作者,华盛顿大学是最主要的贡献机构,Journal of Biological Chemistry是胰岛素瘤领域发文的主要期刊。关键词分析显示,目前重点主要集中在“Pancreatic Neuroendocrine Tumor”“ENTS Consensus Guideline”“Marker”“Management”“Neoplasm”等,这表明胰岛素瘤的重点已逐渐从单纯的对此疾病的概述、诊断、临床表现、并发症等转为对神经内分泌肿瘤这一大类的探索。结论:近20年来,胰岛素瘤的发文量始终保持在一个高度爆发的状态。美国在这一领域有着不可动摇的地位。此外,新兴肿瘤标志物的效果及如何制定更为合理的管理模式极有可能成为未来的研究热点。本研究将有助于预测胰岛素瘤相关领域的发展和趋势。

Background and Aims:Insulinoma is the most common functional neuroendocrine tumor of the pancreas.However,there have been few bibliometric studies on insulinoma.Therefore,this study was conducted to describe the hotspots and trends in insulinoma research over the past 20 years through bibliometricanalysis.Methods:Publications related to insulinoma between 1999 and 2021 were searched in the Web of Science Core Collection(WoSCC),and the results were imported in plain text format into VOSviewer and CiteSpace software for bibliometric analysis.The data was processed using bibliometric methods to conduct visual analysis of authors,countries,institutions,highly cited works,co-citations,keywords,and references.Results:A total of 3863 publications were retrieved,including 19310 authors,3268 organizations,83 countries/regions,and 1005 journals.The literature cited a total of 85078 articles authored by 55619 individuals from 7494 journals.Among them,research on insulinoma was mainly conducted in the United States,with Lernmark A being the most prolific author and the University of Washington being the most significant contributor.The Journal of Biological Chemistry was the main journal for publishing research in the insulinoma field.Keyword analysis showed that the current focus is mainly on"Pancreatic Neuroendocrine Tumor""ENTS Consensus Guideline""Marker""Management"and"Neoplasm"indicating that the focus of insulinoma research has gradually shifted from a simple overview,diagnosis,clinical manifestations,and complications of this disease to the exploration of neuroendocrine tumors as a whole.Conclusions:In the past 20 years,the publication output of insulinoma has remained at a highly explosive level.The United States has an unshakable position in this field.In addition,the efficacy of emerging tumor markers and how to develop more rational management modes are likely to become future research hotspots.Our study will help predict the development and trends in the field of insulinoma.