抗菌药物在牙髓血运重建术中的应用

The application of antimicrobial agents in regenerative endodontic procedures

目前牙髓血运重建术是治疗牙髓坏死性年轻恒牙的主要治疗方法之一。牙髓血运重建治疗的关键在于控制根管内的感染以及促进根尖区干细胞的增殖分化潜能。因此在临床应用中如何选用适当的消毒药物达到既能控制年轻恒牙的感染,又能保护根尖区干细胞的目的,对治疗后促使牙根后续发育以及保存牙齿、维持牙列完整具有重要意义。本文对牙髓血运重建术中目前常用的根管消毒药物的抗菌特点、根尖干细胞生物相容性、用药方式和二者临床应用疗效方面作一综述,为临床治疗中消毒药物的选择提供参考。

Regenerative endodontics is one of the main therapies for immature teeth with pulp necrosis.Its key goals involve controlling infection in the root canal and promoting the proliferation and differentiation potential of apical stem cells.Therefore,it is essential to choose appropriate antimicrobial therapeutics for clinical application,which can control the infection of immature teeth and protect apical stem cells thus promoting the continued development of the root,preserving teeth and maintaining the integrity of dentition after treatment.This paper reviews the antibacterial characteristics of common root canal disinfectant drugs used in endodontic regeneration procedures,the biocompatibility of apical stem cells,medication methods and the clinical application efficacy of both,so as to provide a reference for the selection of antimicrobial agents in clinical treatment.