慢性自发性荨麻疹发病机制的研究进展

Progress in the pathogenesis of chronic spontaneous urticaria

慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)是一种常见肥大细胞驱动的皮肤病,具有病程迁延、复发率高等特征。CSU发病机制极为复杂,目前在研究其自身免疫机制方面已取得了很大进展。本文回顾了CSU与自身免疫和非自身免疫(凝血级联反应和补体、细胞因子失衡以及微生物感染等)之间的关系,并重点阐述了CSU自身免疫发病机制的证据,这些证据表明该疾病的发生发展离不开自身抗体参与。深入解析CSU发病机制,将有助于我们挖掘新的研究理念和治疗靶点,为CSU患者带来福音。

Chronic spontaneous urticaria(CSU)is a common skin disease driven by mast cells with prolonged course and high recurrence rate.The pathogenesis of CSU is very complex,and great progress has been achived in the study of its autoimmune mechanism.This article reviews the relationship of CSU with autoimmunity and/or nonautoimmunity(coagulation cascade and complement,cytokine imbalance,and microbial infection,etc.)and highlights the evidence of the autoimmune pathogenesis of CSU,which shows that autoantibodies are involved in the development of the disease.In-depth analysis of the pathogenesis of CSU will help us explore new research concepts and therapeutic targets of CSU.