神经免疫在抑郁症发病机制中的研究进展

Research progress of neuroimmune response in the pathogenesis of the depressive disorder

抑郁症的病理生理过程复杂,既往研究对其发病机制的了解仍相对有限。近年来神经免疫机制引起了广泛关注,中枢神经系统和外周免疫系统之间的双向通信已被证实在抑郁症中发挥了重要作用。本文对神经免疫在抑郁症患者和抑郁症动物模型中的研究进展作一综述,以期为抑郁症的治疗提供潜在思路。

The pathophysiology of depressive disorder is complex.However,the understanding of its pathogenesis is still relatively limited in previous studies.In recent years,the neuroimmune mechanism has received extensive attention.The bidirectional communication between the central nervous system and the peripheral immune system has been identified to play an important role in depressive disorder.This article reviews the research progress of neuroimmune response in patients with depressive disorders and animal models of depression to raise considerations for the treatment of depressive disorder.