类风湿关节炎患者血清RF、ACCP、CD4^(+)/CD8^(+)水平及相关性分析

Serum RF,ACCP,CD4^(+)/CD8^(+)expression and correlation analysis in patients with rheumatoid

目的探讨类风湿关节炎(RA)患者血清类风湿因子(RF)、抗环瓜氨酸肽抗体(ACCP)、CD4^(+)/CD8^(+)水平及其相关性。方法选取2020年10月至2022年6月该院收治的96例RA患者作为RA组,另选取同期96例健康体检者作为对照组。比较两组入组时、不同活动度RA患者及治疗前、治疗1个月后、治疗3个月后RA患者血清RF、ACCP、CD4^(+)/CD8^(+)水平,分析血清ACCP、CD4^(+)/CD8^(+)水平与28处关节疾病活动度(DAS28)评分及RF水平的相关性。结果与对照组比较,RA组入组时血清RF、ACCP、CD4^(+)/CD8^(+)水平均高于对照组,差异均有统计学意义(P<0.05);轻度活动度组RA患者RF、ACCP、CD4^(+)/CD8^(+)水平均低于中度活动度组,中度活动度组RA患者RF、ACCP、CD4^(+)/CD8^(+)水平均低于重度活动度组,差异均有统计学意义(P<0.05);治疗前RA患者RF、ACCP、CD4^(+)/CD8^(+)水平均高于治疗1个月后,治疗后1个月后RA患者RF、ACCP、CD4^(+)/CD8^(+)水平均高于治疗3个月后,差异均有统计学意义(P<0.05)。血清ACCP水平、CD4^(+)/CD8^(+)水平与DAS28评分及RF水平均呈正相关(P<0.05)。结论血清RF、ACCP、CD4^(+)/CD8^(+)水平在RA患者中呈异常表达,动态监测其水平可评估RA的病情变化,可为临床治疗方案的制订提供参考依据。

Objective To investigate the expression levels and correlations of serum rheumatoid factor(RF),anti-cyclic citrullinated peptide antibody(ACCP)and CD4^(+)/CD8^(+)in patients with rheumatoid arthritis(RA).Methods A total of 96 RA patients admitted to the First People′s Hospital of Pingdingshan City from October 2020 to June 2022 were selected as the RA group,and 96 healthy subjects during the same period were selected as the control group.The expression levels of serum RF,ACCP,CD4^(+)/CD8^(+)in RA patients at the time of admission,different activity levels,before treatment,1 month and 3 months after treatment were compared between the two groups,and the correlation between serum ACCP,CD4^(+)/CD8^(+)expression levels and activity of 28 joint diseases(DAS28)score and RF levels were analyzed.Results Compared with the control group,the serum RF,ACCP,CD4^(+)/CD8^(+)expression levels of the RA group were higher at admission(P<0.05).The serum RF,ACCP,CD4^(+)/CD8^(+)expression levels of RA patients with mildly activity were significantly lower than that of RA patients with moderately activity(P<0.05).And the serum RF,ACCP,CD4^(+)/CD8^(+)expression levels of RA patients with moderately activity were significantly lower than that of RA patients with severely activity(P<0.05).Serum RF,ACCP,CD4^(+)/CD8^(+)expression levels of RA patients before treatment were significantly higher than that of 1 month of treatment.In addition,serum RF,ACCP,CD4^(+)/CD8^(+)expression levels of RA patients 1 month of treatment were significantly higher than that of 3 months of treatment(P<0.05).Serum ACCP level,serum CD4^(+)/CD8^(+)level were positively correlated with DAS28 score and RF level(P<0.05).Conclusion Serum RF,ACCP,CD4^(+)/CD8^(+)expression levels are abnormally expressed in RA patients,and dynamic monitoring of their expression levels can evaluate the changes of the disease and provide a reference for the formulation of clinical treatment plans.