妇科千金胶囊联合替硝唑注射液、注射用头孢呋辛钠治疗慢性盆腔炎的疗效及血清炎症因子水平分析

Analysis of curative effect and serum inflammatory factor levels of Fuke Qianjin capsule combined with tinidazole and cefuroxime sodium for injection in patients with chronic pelvic inflammatory disease

目的探讨妇科千金胶囊联合替硝唑注射液、注射用头孢呋辛钠治疗慢性盆腔炎的疗效及对血清炎症因子水平的影响。方法选取2019年5月至2021年10月该院收治的138例慢性盆腔炎患者作为研究对象,采用随机数字表法分为A组和B组,每组各69例。A组患者采用妇科千金胶囊联合替硝唑注射液、注射用头孢呋辛钠治疗,B组患者采用替硝唑注射液、注射用头孢呋辛钠治疗。比较两组患者临床疗效、临床症状缓解时间、血液流变学指标水平、血清炎症因子[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平、巨噬细胞集落刺激因子(GM-CSF)水平及复发率。结果A组患者治疗2周后总有效率[97.10%(67/69)]高于B组[85.51%(59/69)],临床症状缓解时间短于B组,血液流变学指标水平、血清IL-6、hs-CRP、TNF-α、GM-CSF水平均低于B组,差异均有统计学意义(P<0.05);随访6个月,A组患者复发率[6.06%(4/66)]低于B组[20.31%(13/64)],差异有统计学意义(P<0.05)。结论妇科千金胶囊联合替硝唑注射液、注射用头孢呋辛钠治疗慢性盆腔炎可进一步提高疗效,缓解临床症状,减轻炎症反应,调节血液流变学指标,降低复发风险。

Objective To study the efficacy of Fuke Qianjin Capsule combined with tinidazole and cefuroxime sodium for injection in the treatment of patients with chronic pelvic inflammatory disease and the effect on serum inflammatory factor levels.Methods A total of 138 patients with chronic pelvic inflammatory disease who were admitted to our hospital from May 2019 to October 2021 were selected as the research objects.The patients were divided into group B and group A by the digital table method,with 69 cases in each group.Group B was treated with tinidazole and cefuroxime sodium for injection,and group A was treated with Fuke Qianjin capsule combined with tinidazole and cefuroxime sodium for injection.The clinical efficacy,clinical symptom remission time,hemorheology index serum inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],macrophage colony stimulating factor(GM-CSF)level,recurrence rate and serum inflammatory factors were compared between the two groups.Results The total effective rate of group A was 97.10%(67/69),which was higher than that of group B[85.51%(59/69)],difference was statistically significant(P<0.05).After 2 weeks of treatment,the clinical symptom relief time of group A was shorter than that of group B(P<0.05).After 2 weeks of treatment,the levels of hemorheological indexes in group A were lower than those in group B(P<0.05),the levels of serum IL-6,hs-CRP,TNF-αand GM-CSF in group A were significantly lower than those in group B after 2 weeks of treatment(P<0.05).The recurrence rate of group A was 6.06%(4/66),which was significantly lower than that of group B[20.31%(13/64)]after 6 months of follow-up(P<0.05).Conclusion Fuke Qianjin capsule combined with tinidazole injection and cefuroxime sodium for injection in the treatment of chronic pelvic inflammatory disease can further improve the efficacy,alleviate clinical symptoms,reduce inflammatory reaction,regulate hemorheology indicators,and reduce the risk of recurrence.