2004-2021年浙江省报告丙型肝炎病例特征分析

Epidemiological characteristics of hepatitis C in Zhejiang Province from 2004 to 2021

目的分析浙江省2004-2021年丙型肝炎(简称丙肝)病例流行病学特征,为实现2030年消除丙肝公共卫生危害目标提供基础数据。方法通过“中国疾病预防控制信息管理系统”收集2004-2021年报告丙肝病例数据,对浙江省丙肝报告病例数和报告感染率进行分析,并通过SAS 9.4软件Cochran-Armitage趋势检验方法进行报告感染率的趋势分析。同时对报告病例的年龄、性别和职业的分布特点和重点地市的报告病例数和报告感染率的趋势进行描述。结果浙江省丙肝报告感染率呈上升趋势(Z=69.539,P<0.001),报告病例数从2004年的978例上升到2021年的3520例。其中杭州市、宁波市、温州市、台州市的报告病例数较高且呈上升趋势,Cochran-Armitage趋势检验分析结果分别为Z=6.717,P<0.001;Z=45.941,P<0.001;Z=35.445,P<0.001;Z=16.595,P<0.001。男性报告病例数高于女性,男女性别比从2004年的2.02∶1下降至2021年的1.72∶1。病例年龄主要集中在15~49岁,50岁及以上人群构成比逐年上升,从2004年的27.61%上升到2021年的41.45%。职业主要为农民/民工。结论浙江省丙肝疫情处于低流行水平,整体呈上升趋势,部分地市病例数较多,报告病例人群特征男性高于女性、以农民/民工人群为主,15~49岁虽然是主要人群,但50岁及以上人群上升明显。

Objective To analyze the epidemiological characteristics of hepatitis C in Zhejiang Province from 2004to 2021 to provide data for eliminating hepatitis C as a public health hazard.Methods The data on hepatitis C in Zhejiang Province from 2004 to 2021 were collected from the infectious disease surveillance system of the China Information System for disease control and prevention.Distribution analysis and Cochran-Armitage analysis were used by SAS 9.4 software.Distribution of characteristics of age,gender,occupation,and key cities of reported cases and trend analysis in Zhejiang from 2004-2021.Results HCV reported infection rate was up trend(Z-value=69.539,P<0.001),number of reported cases were from 978 in 2004 to 3520 in 2021.Wenzhou,Hangzhou,Ningbo,and Taizhou city were reported a higher number of cases with an increasing trend.Cochran-Armitage testing was Z=6.717,P<0.001;Z=45.941,P<0.001;Z=35.445,P<0.001;Z=16.595,P<0.001 respectively.The number of males was higher than females,decreasing from 2.02∶1 in 2004 to 1.72∶1 in 2021.The highest cases was among 15-49 years old.The proportion of 50 years old and above was increased from 27.61%in 2004 to 41.45%in 2021.Main occupation were farmers/migrant workers.Conclusions Zhejiang province’s prevalence of hepatitis C was at a low level,but with an up trend.Reported cases were high in some cities and male higher than female.Although 15-49 years old is the main population,the number of people over 50 has increased significantly.