摘要
淋球菌对阿奇霉素耐药比例逐年增加。国内已不推荐阿奇霉素作为治疗淋病的主要药物。淋球菌对阿奇霉素高度耐药机制主要为23S rRNA基因A2059G突变,核糖体蛋白编码突变、多重可转移耐药性(Mtr)系统突变和镶嵌状Mtr发挥了重要的作用,erm家族基因和MacA-MacB外排泵基因突变可能与淋球菌对阿奇霉素耐药相关。
Genitourinary tract infection caused by Neisseria gonorrhoeae is a common sexually transmitted disease,and the proportion of azithromycin-resistant strains of Neisseria gonorrhoeae is increasing year by year.The mechanism of azithromycin resistance mainly acts through 23S rRNA gene locus mutation,ribosomal protein-coding mutation,and multiple transferable drug resistance(Mtr)system mutations.
作者
张玉妍
蒋法兴
ZHANG Yuyan;JIANG Faxing(Department of Dermatology,Wannan Medical College,Wuhu 241002,China;Department of Dermatology,The First Affiliated Hospital of USTC,Hefei 230001)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2023年第3期363-366,共4页
Chinese Journal of Aids & STD
关键词
淋球菌
阿奇霉素
耐药
Neisseria gonorrhoeae
azithromycin
antimicrobial resistance
