小剂量阿司匹林联合硝苯地平治疗妊娠高血压的效果及对妊娠结局的影响

Effect of Low-dose Aspirin Combined with Nifedipine on Pregnancy Hypertension and Its Influence on Pregnancy Outcome

目的 探讨在妊娠高血压治疗中小剂量阿司匹林联合硝苯地平方案的临床效果。方法 选取2020年9月至2021年9月运城市中心医院产科收治的83例妊娠高血压患者作为研究对象,遵循伦理学要求的基础上随机分为试验组(n=44)和对照组(n=39)。对照组单用硝苯地平,试验组联用小剂量阿司匹林,比较两组的血压控制效果和妊娠结局。结果 试验组治疗后收缩压(DBP)、舒张压(SBP)、内皮素(ET)低于对照组,一氧化氮(NO)高于对照组,差异有统计学意义(P<0.05)。试验组治疗后凝血活酶时间(APTT)、凝血酶原时间(PT)高于对照组,纤维蛋白原(FIB)低于对照组,差异有统计学意义(P<0.05)。试验组治疗后白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)均低于对照组(P<0.05)。试验组自然分娩率77.27%,高于对照组的56.41%(P<0.05)。试验组不良妊娠事件发生率11.36%,低于对照组的30.77%(P<0.05)。结论 硝苯地平与小剂量阿司匹林联合治疗妊娠高血压效果确切,可明显防止各类不良妊娠事件的发生。

Objective To explore the clinical effect of small dose aspirin combined with nifedipine in the treatment of hypertensive patients during pregnancy.Methods A total of 83 patients with gestational hypertension admitted to the Department of Obstetrics of Yun Cheng Central Hospital from September 2020 to September 2021 were selected as the research objects.Patients were randomly divided into experimental group(n-44)and control group(n=39)on the basis of ethical requirements.The control group was treated with nifedipine alone,while the experimental group was treated with low-dose aspirin.The blood pressure control effect and pregnancy outcome were compared between the two groups.Results After treatment,the systolic blood pressure(DBP),diastolic blood pressure(SBP)and vascular endothelin(ET)in the experimental group were lower than those in the control group,and the nitric oxide(NO)was higher than that in the control group(P<0.05).After treatment,the thrombin time(APTT)and prothrombin time(PT)in the experimental group were higher than those in the control group,and the fibrinogen(FIB)was lower than that in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor(TNF-a)in the experimental group were lower than those in the control group(P<0.05).The natural delivery rate of the experimental group was 77.27%,which was higher than 56.41%of the control group(P<0.05).The incidence of adverse pregnancy events in the experimental group was 11.36%,which was lower than 30.77%in the control group(P<0.05).Conclusion The combination of nifedipine and low-dose aspirin in the treatment of hypertension during pregnancy is effective and can significantly reduce the occurrence of various adverse pregnancy events.