未足月胎膜早破患者血常规指标的logistic回归分析

Logistic regression analysis of blood routine indexes in patients with preterm premature rupture of membranes

目的探讨血常规指标对未足月胎膜早破(preterm premature rupture of membranes,PPROM)的预测价值。方法回顾性分析2020年9月至2021年9月在郑州大学第三附属医院住院治疗生产并符合纳入标准的100例未足月胎膜早破孕妇作为观察组,选择同期住院分娩的100例健康孕妇作为对照组,收集患者的年龄、既往孕产史及流产史、入院时的血常规指标。单因素分析两组之间的差异,并采用多因素二分类logistic回归分析和ROC曲线分析探讨血常规指标对PPROM的预测价值。结果单因素分析示:观察组与对照组WBC(×10^(9))、%NEUT(%)、%LYMPH(%)、%MONO(%)、RBC(×10^(12))、HGB(g/L)、HCT(%)、RDW-CV(%)、RDW-SD(fL)、PLT(×10^(9))、MPV(fL)、PDW(fL)比较,差异均有统计学意义(P<0.05),观察组的WBC(×10^(9))、%NEUT(%)、PLT(×10^(9))均高于对照组,观察组的%LYMPH(%)、%MONO(%)、RBC(×10^(12))、HGB(g/L)、HCT(%)、RDW-CV(%)、RDW-SD(fL)、MPV(fL)、PDW(fL)均低于对照组;多因素二分类logistic回归分析示:WBC(OR=1.450,P=0.001),%LYMPH(OR=0.485,P=0.024),MPV(OR=0.554,P=0.033);ROC曲线分析示:WBC的曲线下面积值为0.809,最佳cut-off值为10.250,敏感度是68%,特异度是87%,%LYMPH的曲线下面积值为0.786,最佳cut-off值为15.750,敏感度是69%,特异度是76%,MPV的曲线下面积值为0.686,最佳cut-off值为9.250,敏感度是44%,特异度是84%。结论WBC和%LYMPH对PPROM均有一定的预测价值。

Objective To investigate the predictive value of blood routine indexes for preterm premature rupture of membranes.Methods A retrospective analysis was performed on 100 pregnant women with preterm premature rupture of membranes who were hospitalized in the Third Affiliated Hospital of Zhengzhou University from September 2020 to September 2021 and met the inclusion criteria as the observation group,and 100 healthy pregnant women who were hospitalized in our hospital during the same period were selected as the control group.The patient’s age,previous pregnancy and delivery history,abortion history,and blood routine indicators at admission were collected.Univariate analysis was used to analyze the differences between the two groups,and multivariate binary logistic regression analysis and ROC curve analysis were used to explore the predictive value of blood routine indicators in premature rupture of membranes.Results Univariate analysis showed that:WBC(×10^(9)),%NEUT(%),%LYMPH(%),%MONO(%),RBC(×10^(12)),HGB(g/L),HCT(%),RDW-CV(%),RDW-SD(fL),PLT(×10^(9)),MPV(fL),PDW(fL)were compared between the observation group and the control group,the differences were statistically significant(P<0.05),the WBC(×10^(9)),%NEUT(%)and PLT(×10^(9))of the observation group were higher than those of the control group.The%LYMPH(%),%MONO(%),RBC(×10^(12)),HGB(g/L),HCT(%),RDW-CV(%),RDW-SD(fL),MPV(fL)and PDW(fL)of the observation group were lower than those of the control group.Multiple factors binary logistic regression analysis showed that:WBC(OR=1.450,P=0.001),%LYMPH(OR=0.485,P=0.024),MPV(OR=0.554,P=0.033);ROC curve analysis showed that:The area under the curve(AUC)value of WBC was 0.809,the best cut-off value was 10.250,the sensitivity was 68%,and the specificity was 87%.The AUC value of%LYMPH was 0.786,the best cut-off value was 15.750,the sensitivity was 69%,and the specificity was 76%.The AUC value of MPV was 0.686,the optimal cut-off value was 9.250,the sensitivity was 44%,and the specificity was 84%.Conclusion WBC and%LYMPH have certain predictive value for preterm premature rupture of membranes.