血清UCH-L1、GFAP水平与老年脑梗死患者颈动脉狭窄的相关性

Correlation between serum UCH-L1,GFAP levels and carotid stenosis in elderly patients with cerebral infarction

目的 探讨血清泛素羧基末端水解酶L1(UCH-L1)、胶质纤维酸性蛋白(GFAP)水平与老年脑梗死患者颈动脉狭窄的相关性。方法 选取2018年6月—2020年10月在长葛市人民医院完成治疗的94例老年脑梗死患者,入院时采用数字减影血管造影(DSA)评估颈动脉狭窄发生状况并分组(颈动脉狭窄组和无颈动脉狭窄组);治疗前均行血清UCH-L1、GFAP检测,查阅患者临床资料收集并对比两组一般资料及血清UCH-L1、GFAP水平,重点分析血清UCH-L1、GFAP水平与老年脑梗死患者颈动脉狭窄的相关性。结果 颈动脉狭窄组血清UCH-L1、GFAP水平分别为(0.45±0.09)μg/L、(2.57±0.60)ng/L,均高于无颈动脉狭窄组的(0.33±0.05)μg/L、(1.77±0.58)ng/L(P<0.05);经logistic回归分析结果提示,血清UCH-L1水平(B=3.624,OR=19.173,95%CI=6.019~58.473)、血清GFA水平(B=2.542,OR=12.710,95%CI=4.118~39.221)高是老年脑梗死患者颈动脉狭窄发生的危险因素(OR>1,P<0.05);绘制受试者工作曲线(ROC)曲线发现,血清UCH-L1、GFAP水平及联合用于预测老年脑梗死患者颈动脉狭窄发生的曲线下面积(AUC)分别为:0.886、0.870及0.889,预测效能较理想,且以联合预测效能最佳。结论 血清UCH-L1、GFAP水平与老年脑梗死患者颈动脉狭窄密切相关,因此早期检测两者水平可能对改善患者预后有积极意义。

Objective To investigate the correlation between the levels of serum ubiquitin carboxyl-terminal hydrolase L1(UCH-L1),glial fibrillary acidic protein(GFAP) and carotid stenosis in elderly patients with cerebral infarction. Methods Totally 94 elderly patients with cerebral infarction who completed treatment in Changge People’s Hospital from June 2018 to October 2020 were selected. The occurrence of carotid stenosis was evaluated at admission by digital subtraction angiography(DSA) and divided into two groups(carotid stenosis group and no carotid stenosis group);Serum UCH-L1 and GFAP were detected before treatment. The clinical data of patients were consulted, and the general data and serum UCH-L1 and GFAP levels of the two groups were collected and compared. The correlation between serum UCH-L1 and GFAP levels and carotid stenosis in elderly patients with cerebral infarction was mainly analyzed. Results The levels of serum UCH-L1 and GFAP in carotid stenosis group were(0.45±0.09) μg/L,(2.57±0.60) ng/L,respectively, which were higher than those in the no carotid stenosis group(0.33±0.05) μg/L,(1.77±0.58) ng/L(P<0.05);The results of logistic regression analysis showed that high levels of serum UCH-L1(B=3.624,OR=19.173,95% CI=6.019-58.473) and serum GFA(B=2.542,OR=12.710,95% CI=4.118-39.221) were the risk factors of carotid stenosis in elderly patients with cerebral infarction(OR>1,P<0.05);By plotting the receiver operating curve(ROC),it was found that the area under the curve(AUC) of serum UCH-L1 and GFAP levels and their combination for predicting the occurrence of carotid stenosis in elderly patients with cerebral infarction were 0.886,0.870 and 0.889 respectively. The prediction efficiency was ideal, and the joint prediction efficiency was the best. Conclusion The levels of serum UCH-L1 and GFAP are closely related to carotid stenosis in elderly patients with cerebral infarction. Therefore, early detection of their levels may be of positive significance to improve the prognosis of patients.