原发性肝癌患者组织中PD-L1、Gab1表达及临床意义分析

Analysis of expression and clinical significance of PD-L1 and Gab1 in tissues of patients with primary liver cancer

目的 探讨原发性肝癌(primary carcinoma cancer, PLC)患者组织中程序性死亡受体-1(PD-L1)、生长因子受体结合蛋白-1(Gab1)表达及临床意义。方法 采取回顾性研究,收集2019年2月至2021年2月信阳市中心医院收治的PLC患者临床资料。所有患者均接受PD-L1、Gab1检查,并分析PLC患者组织中PD-L1、Gab1水平与病理特征关系。结果 肿瘤分期Ⅲ/Ⅳ期患者PD-L1阳性33例(68.75%)、Gab1阳性31例(64.58%),肿瘤转移PLC患者PD-L1阳性31例(75.61%)、Gab1阳性28例(68.29%),高于肿瘤分期Ⅰ/Ⅱ期患者PD-L1阳性12(37.50),Gab1阳性8例(25.00%),无肿瘤转移患者PD-L1阳性12例(30.77%)、Gab1阳性10例(25.64%),差异有统计学意义(P<0.05);绘制受试者工作特征(ROC)曲线结果显示,PD-L1、Gab1阳性表达预测PLC肿瘤分期Ⅲ/Ⅳ、肿瘤转移的曲线下面积(AUC)均>0.7(PD-L1预测肿瘤分期Ⅲ/Ⅳ期的AUC为0.719,Gab1预测肿瘤分期Ⅲ/Ⅳ期的AUC为0.708,PD-L1预测肿瘤转移的AUC为0.724,Gab1预测肿瘤转移的AUC为0.713),具有一定预测价值。结论 PLC患者组织中PD-L1、Gab1呈异常表达,且与PLC患者病理特征密切相关。

Objective To investigate the expression and clinical significance of programmed death-ligand 1(PD-L1) and growth factor receptor binding protein-1(Gab1) in tissues of patients with primary liver cancer(PLC). Methods A retrospective study was conducted, the clinical data of PLC patients admitted to Xinyang Central Hospital from February 2019 to February 2021 were collected as the research subjects. all patients underwent PD-L1 and Gab1 examination, the relationship between PD-L1, Gab1 levels and pathological features in tissues of PLC patients was analyzed. Results Totally 33 cases(68.75%) were PD-L1 positive in tumor stage III/IV, 31 cases(64.58%) were Gab1 positive, 31 cases(75.61%) were PD-L1 positive and 28 cases(68.29%) were Gab1 positive in PLC patients with tumor metastasis, which was higher than 12 cases(37.50%) in tumor stage I/II, 8 cases(25.00%) were Gab1 positive, 12 cases(30.77%) were PD-L1 positive and 10 cases(25.64%) were Gab1 positive in tumor stage I/II(P<0.05);The ROC curve was drawn, and the results showed that the AUC of PD-L1 and Gab1 positive expression in predicting PLC tumor stage Ⅲ/Ⅳ and metastasis were all >0.7(AUC of PD-L1 predicting tumor stage Ⅲ/Ⅳ: 0.719, AUC of Gab1 predicting tumor stage Ⅲ/Ⅳ: 0.708, AUC of PD-L1 predicting tumor metastasis: 0.724, AUC of Gab1 predicting tumor metastasis: 0.713), which had certain predictive value. Conclusion PD-L1 and Gab1 in tissues of PLC patients are abnormally expressed, which is closely related to the pathological characteristics of PLC patients.