摘要
美国国立卫生院(NIH)于2016年启动的“刺激外周神经缓解疾病症状”(SPARC)计划,已于2022年开展Ⅱ期研究。与Ⅰ期关注整体外周神经系统相比,SPARC计划Ⅱ期的最大特点在于专注研究迷走神经。通过梳理迷走神经刺激(VNS)临床应用现状、迷走神经与炎症反射、迷走神经与内感受系统等前沿进展,探索了SPARC计划Ⅱ期聚焦迷走神经的原因,提出了迷走神经感觉神经元的识别和研究范式,对揭示针灸作用于体表-脏腑的机制原理具有启发和借鉴意义。
"Stimulating Peripheral Activity to Relieve Conditions"program(SPARC),which was initiated by the National Institutes of Health(NIH)in 2016,has been proceed to the next stage in 2022.Compared with the first stage,which focused on the peripheral nervous system as a whole,the most important feature of the SPARC Phase II is its focus on the vagus nerve.This paper explores the reasons for the focus of Phase Il by sorting out the curent status of the clinical application of vagus nerve stimulation(VNS),the vagus nerve and inflammatory reflexes,and the vagus nerve and the introception system.More importantly,the identification and study paradigm of vagal sensory neurons is enlightening and informative to reveal the mechanism of acupuncture acting on the body's surface and visceral organs.
作者
辛陈
荣培晶
李少源
王瑜
陈瑜
陈建德
魏玮
丛斌
XIN Chen;RONG Peijing;LI Shaoyuan;WANG Yu;CHEN Yu;CHEN Jiande;WEI Wei;CONG Bin(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;Division of Gastroenterology and Hepatology,University of Michigan,Ann Arbor 48109,USA;Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Department of Forensic Medicine,Hebei Medical University,Shijiazhuang 050017,China)
出处
《科技导报》
CAS
CSCD
北大核心
2023年第6期121-126,共6页
Science & Technology Review
基金
国家自然科学基金项目(82174519)
国家重点研发计划专项(2022YFC3500500,2022YFC3500501)
国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目([2021]203号)。
