血清SCCA、CEA及CYFRA21-1联合检测在宫颈癌诊断中的临床价值

Clinical value of combined detection of serum SCCA, CEA and CYFRA21-1in the diagnosis of cervical cancer

目的 探讨血清鳞状上皮细胞癌抗原(SCCA)、癌胚抗原(CEA)及细胞角蛋白19片段(CYFRA21-1)联合检测在宫颈癌诊断中的临床价值。方法 选择2019年6月—2021年6月我院收治的52例宫颈癌患者为甲组,随机抽取同期健康体检者52例为乙组,检测两组血清SCCA、CEA、CYFRA21-1水平。结果 甲组SCCA、CEA、CYFRA21-1水平均显著高于乙组,两组比较差异均有统计学意义(t=38.268、15.381、34.455,均P<0.05);甲组宫颈癌不同分期的SCCA、CEA、CYFRA21-1水平比较差异均有统计学意义(t=25.856、20.781、31.773,均P<0.05);联合检测的阳性率均高于单一SCCA、CEA、CYFRA21-1检测,上述检测方法比较差异均有统计学意义(χ2=30.583、24.471、31.312,均P<0.05);联合检测的诊断敏感度、准确度均明显高于单一检测,上述检测方法比较差异均有统计学意义(χ2=8.569、6.325,均P<0.05);联合检测与单一检测诊断方法的特异度比较差异无统计学意义(χ2=0.158,P>0.05)。结论 宫颈癌患者的血清SCCA、CEA和CYFRA21-1水平与健康人存在显著差异,可通过联合检测提高诊断的准确性,为治疗提供数据支持。

Objective To explore the clinical value of combined detection of serum squamous cell carcinoma antigen(SCCA),carcinoembryonic antigen(CEA)and cytokeratin 19 fragment(CYFRA21-1)in patients with cervical cancer.Methods A total of 52 patients with cervical cancer admitted to our hospital from June 2019 to June 2021 were selected as group A.52 healthy subjects in the same time period were randomly selected as group B.The levels of serum SCCA,CEA and CYFRA21-1 in the two groups were detectioned.Results The levels of SCCA,CEA and CYFRA21-1 in group A were all significantly higher than those in group B.The differences between the two groups were statistically significant(t=38.268,15.381,34.455,all P<0.05);the differences between the level of SCCA,CEA and CYFRA21-1 in different stages of cervical cancer in group A were statistically significant(t=25.856,20.781,31.773,all P<0.05);the positive rate of combined detection was higher than those of single serum SCCA,CEA and CYFRA21-1,and the differences between the above detections were statistically significant(χ2=30.583,24.471,31.312,all P<0.05);the diagnostic sensitivity and accuracy of combined detection were significantly higher than those of single detection.The differences were statistically significant when comparing the above detections(χ2=8.569,6.325,both P<0.05);the differences between the specificity of the combined detection and the single detection were not statistically significant(χ2=0.158,both P>0.05).Conclusion The levels of serum SCCA,CEA and CYFRA21-1 in patients with cervical cancer are significantly different from those in healthy people.Combined detection can improve the diagnostic accuracy and provide data support for treatment.