病毒感染与细胞自噬的交互作用

Interaction between viral infection and autophagy

细胞自噬为机体维持内环境稳定并降解胞内成分的一种溶酶体清除程序。在病毒感染过程中,自噬发挥双向作用。自噬可以在固有免疫中通过自噬溶酶体直接消化清除胞内病原体,另一方面,病毒也会影响或利用自噬使自身得以逃避机体免疫反应。文章就病毒感染与细胞自噬的交互作用作一综述。

Autophagy is a lysosomal clearance procedure for maintaining homeostasis and degrading intracellular components.In the process of virus infection,autophagy plays a bidirectional role.Autophagy contributes to innate immunity by directly eliminating intracellular pathogens through digestion in autolysosomes.On the other hand,viruses can also affect or use autophagy to escape the immune response of the body.This review summarizes the interaction between viral infection and autophagy.