瑞马唑仑降低小儿七氟烷麻醉后躁动发生率的效果及安全性

Effect and Safety of Remazolam in Reducing Incidence of Agitation After Sevoflurane Anesthesia in Children

目的:探讨瑞马唑仑降低小儿七氟烷麻醉后躁动发生率的效果及安全性,为提高儿科麻醉质量提供参考。方法:选取2020年3月至2021年3月联勤保障部队第九〇〇医院收治的需行腹腔镜疝囊高位结扎手术患儿90例,按随机数表法分为A组与B组各45例,A组患儿给予七氟烷麻醉,B组给予瑞马唑仑联合七氟烷麻醉,比较两组患儿麻醉效果(麻醉诱导时间、呼吸恢复时间、苏醒时间、拔管时间)、生命体征变化情况(平均动脉压、心率)、苏醒期躁动情况[苏醒期躁动(PAED)评分、激动(Watcha)评分、躁动发生率]及不良反应发生情况。结果:B组患儿麻醉诱导时间、呼吸恢复时间、苏醒时间均短于A组(P<0.05)。B组麻醉诱导时、术毕时、清醒时平均动脉压与心率均高于A组(P<0.05)。B组PAED评分、Watcha评分及躁动发生率低于A组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:瑞马唑仑在小儿七氟烷麻醉中的应用效果显著,可提高麻醉效果,稳定患儿生命体征,降低小儿七氟烷麻醉后躁动发生率,且不增加不良反应,有效性与安全性均较高。

Objective:To observe the effect and safety of remazolam in reducing the incidence of agitation after sevoflurane anesthesia in children,and to provide theoretical support for improving the quality of anesthesia in children.Methods:A total of 90 children who needed laparoscopic high ligation of hernia sac in the Department of Anesthesia and Perioperative Medicine of The 900 th Hospital of Joint Logistics Support Force,PLA from March 2020 to March 2021 were randomly divided into group A and group B,with 45 cases in each group.Group A was given sevoflurane anesthesia,and group B was given combined anesthesia of remazolam and sevoflurane.The anesthetic effect(anesthesia induction time,respiratory recovery time,awakening time,extubation time),changes of vital signs(mean arterial pressure,heart rate),agitation during recovery such as pediatric anesthesia emergence delirium(PAED)score,Watcha score,incidence of agitation and adverse reactions were compared between the two groups.Results:The anesthesia induction time,respiratory recovery time and awakening time in group B were shorter than those in group A(P<0.05).The mean arterial pressure and heart rate in group B were higher than those in group A(P<0.05).The PAED score and Watcha score of group B were higher than those of group A,and the incidence of agitation was lower in group B than in group A(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application effect of remazolam in sevoflurane anesthesia in children is significant,which can improve the anesthetic effect,stabilize the vital signs of children,reduce the incidence of agitation after sevoflurane anesthesia in children,and does not increase adverse reactions.It has high effectiveness and safety,and is worthy of application.