银杏叶片联合乙酰胆碱酶抑制剂类药物对老年血管性认知障碍患者认知功能及日常生活能力的影响

Effects of Ginkgo Biloba Leaves Combined with Acetylcholinase Inhibitors on Cognitive Function and Daily Living Ability in Elderly Patients with Vascular Cognitive Impairment

目的研究银杏叶片联合乙酰胆碱酶抑制剂类药物对老年血管性认知障碍(VCI)患者认知功能及日常生活能力的影响。方法选择开封市人民医院2018年8月至2020年1月收治的68例老年VCI患者为研究对象,采用随机数字表法将其分为甲组(34例,给予银杏叶片联合乙酰胆碱酶抑制剂类药物)和乙组(34例,仅给予乙酰胆碱酶抑制剂类药物),对比分析两组临床治疗效果、认知功能、神经功能以及日常生活能力恢复情况。结果治疗前,两组各项认知功能、神经功能和日常生活能力评分比较,差异无统计学意义(P>0.05);甲组治疗有效率为94.12%(32/34),高于乙组的76.47%(26/34),差异有统计学意义(P<0.05)。治疗后,两组简易精神状态评定量表(MMSE)中注意力和计算力、定向力、语言能力、记忆力、回忆力等评分均高于治疗前,且甲组上述评分均高于乙组,差异有统计学意义(P<0.05)。治疗后,两组血清丙二醛(MDA)、乙酰胆碱酯酶(AChE)均低于治疗前,超氧化物歧化酶(SOD)高于治疗前,且甲组MDA、AChE均低于乙组,SOD高于乙组,差异有统计学意义(P<0.05)。治疗后,两组日常生活能力量表(ADL)评分均较治疗前高,且甲组ADL评分高于乙组,差异有统计学意义(P<0.05)。结论银杏叶片联合乙酰胆碱酶抑制剂类药物治疗老年VCI效果显著,能够促进患者认知功能改善和神经功能恢复,从而提高患者日常生活能力,促使患者早日恢复正常生活。

Objective To investigate the effects of ginkgo biloba leaves combined with acetylcholinase inhibitors on cognitive function and daily living ability in elderly patients with vascular cognitive impairment(VCI).Methods A total of 68 elderly patients with VCI admitted to Kaifeng People's Hospital from August 2018 to January 2020 were selected as the study objects.They were divided into group A(34 cases receiving ginkgo leaves combined with acetylcholinase inhibitors)and group B(34 cases receiving only acetylcholinase inhibitors)by random number table method.The clinical therapeutic effect,cognitive function,neurological function,and recovery of the daily living ability of the two groups were compared and analyzed.Results Before treatment,there was no significant difference in the scores of cognitive function,neurological function,and daily living ability between the two groups(P>0.05).The effective rate of group A was 94.12%(32/34),higher than that of group B(76.47%(26/34),and the difference was statistically significant(P<0.05).After treatment,the scores of attention and calculation,orientation,language ability,memory,and recall in the mini-mental state examination(MMSE)in the two groups were higher than those before treatment,and the above scores in group A were higher than those in group B,and the differences were statistically significant (P < 0.05). After treatment, serum malondialdehyde (MDA) and acetylcholinesterase (AChE) werelower than before treatment, superoxide dismutase (SOD) was higher than before treatment, and MDA and AChE of group Awere lower than group B, and SOD of group B was higher, the difference was statistically significant (P < 0.05). After treatment,the activities of daily living (ADL) scores of the two groups were higher than those before treatment, and the ADL score of groupA was higher than that of group B, and the difference was statistically significant (P < 0.05). Conclusion Ginkgo biloba leavescombined with acetylcholinase inhibitors have significant effects in the treatment of elderly patients with VCI, which can promotethe improvement of cognitive function and recovery of neurological function, improve patients' ability to daily life and promotepatients to return to normal life as soon as possible.