以脉络学说营卫理论指导心血管事件链的系统干预

Systematic Intervention of Cardiovascular Events Chain following the Vessels and Collaterals Theory and Ying-wei(营卫)Theory

心血管事件链呈因果相连、递进发展、事件突发、后果严重的特征。以脉络学说营卫理论为指导,提出心血管事件链包括高危因素引起的血液凝聚、动脉硬化易损斑块、急性心肌梗死、心肌梗死后心律失常及心力衰竭等关键病理环节,符合脉络病变“凝”→“壅”→“塞”→“不通”传变规律。基于此主张以“治本病,防未病”系统干预心血管事件链,即针对各环节均采取控上游因素、治当前病变、防下游传变治疗策略;同时提出以脉络学说为指导研发系列通络代表药物,系列循证及基础研究数据可为通络药物系统干预心血管事件链提供数据支撑,为临床系统干预心血管事件链提供药物选择。

Cardiovascular events chain is characterized by causal connection,progressive development,sudden onset and severe consequences.Guided by the vessels and collaterals theory and Ying-wei theory,it is considered that the chain of cardiovascular events includes the key pathological progressions such as blood coagulation,atherosclerotic vulnerable plaques,acute myocardial infarction,arrhythmia after myocardial infarction,and heart failure cuased by high-risk factors,which are consistent with the progression law of vessles and collaterals diseases of“coagulation→congestion→obstruction→blocking”.Therefore,it is advocated to systematically intervene in the chain of cardiovascular events by“curing the root disease and preventing the disease before it arises”,that is,adopting treatment strategies to control upstream factors,treating the current diseases and preventing downstream transmission.It is also proposed to develop representative drugs for unblocking collaterals under the guidance of the vessels and collaterals theory.The evidence-based data and basic research data can support the systemic intervention of cardiovascular events chain with collateral-unblocking drugs,and provide clues for the selection of the drugs.