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成都市郫都区女性不同年龄段肿瘤标志物参考区间建立及验证

Establishment and validation of reference interval of tumor markers in women of different ages in Pidu District,Chengdu
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摘要 目的利用大数据建立适用于成都市郫都区健康女性肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)、糖类抗原199(CA199)的参考区间。方法选取2019-2021年于成都市郫都区中医医院健康体检的16880例女性作为研究对象,采用迈克公司i3000全自动化学发光免疫分析仪检测血清AFP、CEA、CA125、CA153、CA199水平,并对数据进行离群值剔除,应用间接法计算相关指标不同年龄的参考区间。结果20~35岁女性AFP参考区间0.00~4.80 IU/mL,CEA参考区间0.00~2.17 ng/mL,CA125参考区间0.00~25.19 U/mL,CA153参考区间0.00~18.64 U/mL,CA199参考区间0.00~20.14 U/mL;>35~50岁女性AFP参考区间0.00~5.63 IU/mL,CEA参考区间0.00~2.57 ng/mL,CA125参考区间0.00~22.37 U/mL,CA153参考区间0.00~20.47 U/mL,CA199参考区间0.00~20.11 U/mL;>50~65岁女性AFP参考区间0.00~5.93 IU/mL,CEA参考区间0.00~3.49 ng/mL,CA125参考区间0.00~16.27 U/mL,CA153参考区间0.00~21.66 U/mL,CA199参考区间0.00~21.49 U/mL;>65岁女性AFP参考区间0.00~5.12 IU/mL,CEA参考区间0.00~4.50 ng/mL,CA125参考区间0.00~15.89 U/mL,CA153参考区间0.00~21.09 U/mL,CA199参考区间0.00~24.50 U/mL。结论建立了该实验室肿瘤标志物的正常参考区间,为更好地筛查不同年龄女性肿瘤相关疾病提供了参考依据。 Objective To establish the reference interval of tumor markers alpha fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)and carbohydrate antigen 199(CA199)for healthy women in Pidu District,Chengdu by using big data.Methods A total of 16880 women who underwent physical examination in Traditional Chinese Medicine Hospital of Pidu District from 2019 to 2021 were selected as the research objects.The levels of serum AFP,CEA,CA125,CA153 and CA199 were detected by Mike's i3000 automatic chemiluminescence immunoanalyzer.The outliers were removed from the data,and the reference interval of related indexes in different ages were calculated by indirect method.Results The reference interval of AFP,CEA,CA125,CA153 and CA199 for women aged 20-35 were 0.00-4.80 IU/mL,0.00-2.17 ng/mL,0.00-25.19 U/mL,0.00-18.64 U/mL and 0.00-20.14 U/mL,respectively.The reference interval of AFP,CEA,CA125,CA153 and CA199 for women aged>35-50 years was 0.00-5.63 IU/mL,0.00-2.57 ng/mL,0.00-22.37 U/mL,0.00-20.47 U/mL and 0.00-20.11 U/mL respectively.The reference interval of AFP,CEA,CA125,CA153 and CA199 for women aged>50-65 years was 0.00-5.93 IU/mL,0.00-3.49 ng/mL,0.00-16.27 U/mL,0.00-21.66 U/mL and 0.00-21.49 U/mL respectively.The reference interval of AFP,CEA,CA125,CA153 and CA199 for>65 year old women was 0.00-5.12 IU/mL,0.00-4.50 ng/mL,0.00-15.89 U/mL,0.00-21.09 U/mL and 0.00-24.50 U/mL respectively.Conclusion The normal reference interval of tumor markers in the laboratory is established to provide reference basis for better screening tumor related diseases in women of different ages.
作者 谢叶红 孔丽蕊 张艳 王华丽 XIE Yehong;KONG Lirui△;ZHANG Yan;WANG Huali(Department of Clinical Laboratory,Traditional Chinese Medicine Hospital of Pidu District,Chengdu,Sichuan 611730,China)
出处 《国际检验医学杂志》 CAS 2023年第8期978-982,共5页 International Journal of Laboratory Medicine
基金 成都市卫生健康委员会医学科研课题(2021192)。
关键词 肿瘤标志物 健康女性 参考区间 成都 tumor marker healthy women reference interval Chengdu
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