复方α-酮酸对行腹膜透析的糖尿病患者生活质量和自我感受负担的影响

Effect of compound α-ketoacid on quality of life and self-perceived burden in diabetic patients undergoing peritoneal dialysis

目的复方α-酮酸对行腹膜透析的糖尿病患者生活质量(QOL)和自我感受负担(SPB)的影响比较。方法将86例在友谊医院接受连续性不卧床腹膜透析(CAPD)3个月以上的糖尿病患者分为观察组(n=44)和治疗组(n=42),口服复方α-酮酸,两组均治疗6个月后用世界卫生组织生存质量评定量表简表(WHOQOL-BREF)评估两组患者生活质量和用自我感受负担量表(SPBS)评估自我感受负担。结果6个月后,治疗组糖化血红蛋白为5.72%±1.03%,显著低于观察组的6.70%±1.17%。治疗组在生理领域、环境领域和总评分显著高于观察组(P<0.05),两组患者在自我感受负担方面差异无统计学意义。结论腹膜透析同时给予α-酮酸补充剂,可显著提高患者的生活质量。

Objective To compare effects of compoundα-ketoacids on quality of life(QOL)and self-perceived burden(SPB)of diabetes patients undergoing peritoneal dialysis.Methods Totally 86 diabetes patients received continuous ambulatory peritoneal dialysis(CAPD)for more than 3 months in Friendship Hospital were divided into observation group(n=44)and treatment group(n=42).After 6 months of treatment,the quality of life of both groups was assessed with the World Health Organization Quality of Life Scale-brief Form Questionnaire(WHOQOL-BREF)and the self-perceived burden was assessed with the Self-perceived Burden Scale(SPBS).Results After 6 months,the glycosylated hemoglobin in the treatment group was 5.72%±1.03%,which was significantly lower than 6.70%±1.17%found in observation group.The physiological field,environmental field and total score of treatment group was significantly higher than those in observation group(P<0.05),and there was no difference was found self-perceived burden.Conclusions Simultaneous administration of peritoneal dialysis plus compoundα-ketoacids supplement may significantly improve the quality of life of diabetes patients.