2型糖尿病肾病患者外周血IL-4、INF-γ及TAFI表达及其与肾小球滤过功能的相关性

Expressions of IL-4,INF-γand TAFI in peripheral blood and their correlation with glomerular filtration function in patients with type 2 diabetic nephropathy

目的:探究2型糖尿病肾病(DN)患者外周血白细胞介素-4(IL-4)、γ-干扰素(INF-γ)、纤溶抑制物(TAFI)表达及其与肾小球滤过功能的相关性。方法:比较分析糖尿病肾病组(n=102)与健康组(n=54)的IL-4、INF-γ及TAFI表达水平;将糖尿病肾病组分为3组,比较分析3组患者的IL-4、INF-γ及TAFI表达水平;采用Spearman分析IL-4、INF-γ及TAFI表达水平与2型DN患者肾小球滤过功能的相关性。结果:糖尿病肾病组IL-4、INF-γ及TAFI水平高于健康组(P<0.05);不同肾功能损伤程度患者IL-4、INF-γ及TAFI比较,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,IL-4与24 h UmAlb负相关(P<0.05),与eGFR、Scr无相关性(P>0.05);INF-γ与eGFR负相关,与Scr、24 h UmAlb正相关(P<0.05);TAFI与eGFR负相关,与Scr、24 h UmAlb正相关(P<0.05)。结论:2型DN患者外周血IL-4、INF-γ及TAFI表达水平与患者的肾小球滤过功能存在相关性,可通过检测外周血IL-4、INF-γ及TAFI的表达水平为2型DN患者肾小球滤过功能的评估和临床治疗提供参考。

Objective:To explore the expressions of interleukin-4(IL-4),γ-interferon(INF-γ)and thrombin activatable fibrinolysis inhibitor(TAFI)in peripheral blood and their correlation with glomerular filtration function in patients with type 2 diabetic nephropathy(DN).Methods:A total of 102 patients with type 2 DN and 54 healthy controls were enrolled as DN group and healthy group.The expression levels of IL-4,INF-γand TAFI in the two groups were compared.According to pathological grading of DN,patients in DN group were divided into 3 groups,and expression levels of IL-4,INF-γand TAFI in the three groups were compared.The correlation between IL-4,INF-γ,TAFI and glomerular filtration function was analyzed by Spearman.Results:The levels of IL-4,INF-γand TAFI in DN group were higher than those in healthy group(P<0.05).There were significant differences in levels of IL-4,INF-γand TAFI among patients with different severity of renal injury(P<0.05).The results of Spearman correlation analysis showed that IL-4 was negatively correlated with 24 h UmAlb(P<0.05),but not correlated with eGFR and Scr(P>0.05).INF-γwas negatively correlated with eGFR,while positively correlated with Scr and 24 h UmAlb(P<0.05).TAFI was negatively correlated with eGFR,while positively correlated with Scr and 24 h UmAlb(P<0.05).Conclusion:The expression levels of peripheral blood IL-4,INF-γand TAFI are correlated with glomerular filtration function in patients with type 2 DN.Detecting IL-4,INF-γand TAFI can provide reference for the evaluation of glomerular filtration function and clinical treatment in patients with type 2 DN.