微生物群的变化在老年性黄斑变性中作用的研究进展

Research progress in the effect of human microorganisms on senile macular degeneration

人类微生物包括定植于人体的细菌、病毒和真菌,这些微生物群落对人体内环境稳态的维持至关重要,微生物稳态失调往往会引发疾病。新近的研究表明,人体内一些微生物群落的变化与老年性黄斑变性(SMD)的发病密切相关,其中肠道菌群的影响较为突出。SMD是一种随着年龄增加而发病率上升并可导致患者中心视力下降、视物变形的疾病,如果不及时干预治疗往往会造成永久视力损害,而人体内微生物参与到SMD中为临床治疗老年性黄斑变性提供了一个新方向,也使得微生物群落成为治疗SMD极具潜力的研究对象。

Human microorganisms include bacteria,viruses and fungi that colonize the human body.These microbial communities are critical to the maintenance of homeostasis in the human body,and disorder of homeostasis often leads to disease.Recent studies have shown that the changes in some microbial communities in the human body,especially the intestinal flora,are closely related to the onset of senile macular degeneration(SMD).SMD,whose incidence rate increases with age,can lead to reduced central vision,distorted vision,and permanent vision damage if left untreated.The involvement of human microorganisms in SMD provides a new idea for the clinical treatment of SMD,and also makes the microbial community a potential research object for the treatment of SMD.