蛋白酶体与衰老的研究进展

Progress in Proteasome and Aging

蛋白酶体由多个亚基结构组成,主要负责清理机体的缺陷蛋白,并维持蛋白质稳态,蛋白酶体系统是控制蛋白质降解的主要途径。多项研究表明,蛋白酶体各结构成分的水平和活性会随着衰老逐渐下降,并影响衰老及衰老相关疾病(如神经退行性疾病等)的发生发展。同时,蛋白酶体活性的降低会引起蛋白质稳态失衡,加速衰老的发生。该文综述了近年来蛋白酶体在衰老领域中的研究进展,旨在阐明蛋白酶体与衰老的关系,为设计预防衰老相关疾病或抗衰老的靶向药物提供理论基础。

Proteasome consists of multiple subunit structures,which can clean up damaged or defective proteins,and maintain protein homeostasis.Proteasome system is the main pathway to control protein degradation.Multiple studies have shown that,the levels and activities of proteasome components gradually decrease with aging,which affect the occurrence and development of aging and age-related diseases,such as neurodegenerative diseases.At the same time,the decrease of proteasome activity will cause the imbalance of protein homeostasis and accelerate the senescence.This work presents an overview of recent research progress of proteasome in the field of aging,aiming to elucidate the relationship between proteasome and aging,which provides a theoretical basis for designing targeted drugs to prevent aging-related diseases or anti-aging.