mTOR信号转导通路抑制剂及其与肿瘤耐药的研究进展

Research Progress of Inhibitors in mTOR Signal Transduction Pathway and Drug Resistance in Tumor

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种特异性的蛋白激酶,在调控细胞生长、增殖、代谢等多项生命活动中都具有重要意义。mTOR调控功能的失活与异常激活,会导致相关肿瘤和疾病的发生。近年来已有多种mTOR抑制剂用于治疗该信号转导通路异常引起的肿瘤。该文探究多种调控mTOR的信号通路和mTOR抑制剂用于肿瘤治疗的最新进展,还探讨肿瘤细胞对mTOR抑制剂产生耐药性的潜在机制和应对策略。因此,对mTOR信号通路及其调控机制的探索有助于研发全新的肿瘤治疗技术。

mTOR(mammalian target of rapamycin)is an evolutionary protein kinase that senses multiple upstream stimuli to regulate cell growth,proliferation,metabolism and many other vital activities.The inactivation and abnormal activation of mTOR regulatory functions will lead to the occurrence of related tumors and diseases.In recent years,a variety of mTOR inhibitors have been used to treat tumors caused by abnormal regulation of this signaling transduction pathway.The latest advances in mTOR inhibitors for tumor treatment are listed,and the potential mechanisms by which tumor cells develop resistance to mTOR inhibitors are also explored.Therefore,in-depth study of the mTOR signal transduction pathway and its regulatory mechanism contributes to the development of new tumor treatment technologies.