miR-21在类风湿性关节炎中的作用机制及研究进展

The Mechanism and Research Progress of miR-21 in Rheumatoid Arthritis

类风湿性关节炎(rheumatoid arthritis,RA)是一种病因未明的慢性自身免疫性疾病,以手、足小关节的多关节和对称性损害为特征。RA的发病机制复杂、病程较长且致残率比较高,严重损害了患者的健康和生活质量。miRNA是近年来研究最多的非编码RNA,在机体的生理和病理过程中发挥重要作用。诸多研究表明,miR-21与RA的发生发展密切相关。因此该文就miR-21在RA中的作用机制及进展进行综述,作用机制主要是miR-21通过与lncRNA的相互作用,靶向SNF5、TET1及调节相关信号通路(Wnt、PI3K/AKT、JAK/STAT和NF-κB)来调控RA,旨在为miR-21与RA的相关研究提供参考及为RA的诊疗提供新策略。

RA(rheumatoid arthritis)is a chronic autoimmune disease of unknown etiology,which is characterized by multiple joints and symmetrical damage to the small joints of the hands and feet.The pathogenesis of RA is complex,the course of disease is long and the morbidity rate is relatively high,which seriously damages the health and quality of life of patients.miRNA is the most studied non-coding RNA in recent years,which plays an important role in the physiological and pathological processes of the body.Many studies have shown that miR-21is closely related to the occurrence and development of RA.Therefore,this paper reviews the mechanism and progress of miR-21 in RA,miR-21 mainly through the interaction with lncRNA,targeting SNF5,TET1 and regulating related signaling pathways(Wnt,PI3K/AKT,JAK/STAT and NF-κB)to regulate RA,aiming to provide a reference for the related research of miR-21 and RA and provide a new strategy for the diagnosis and treatment of RA.