离子导入给药的研究进展

Progress on drug delivery of iontophoresis

离子导入是一种非侵入性的物理促透技术,相较于其他常用促透技术,具有高效、患者依从性好、递送剂量可控等优点,在药物经皮肤、黏膜转运方面具有广阔的应用前景。近年来随着微针、纳米载体等递送技术的发展,离子导入与其他渗透技术的联合应用也逐渐成为研究的热点。本文介绍离子导入给药的转运机制与影响因素,并对该技术与水凝胶、微针和纳米载体等剂型的联合应用的相关研究进行综述和展望。

Iontophoresis is a non-invasive physical permeation technology,which has been widely applied in transdermal and transmucosal administration.Compared with other permeation technologies,iontophoresis have the advantages of high efficacy,high patient compliance and controllable delivery dose.With the development of microneedles and nano-carrier technology,the combination of iontophoresis and other penetration promotion technologies has gradually become a research hotspot.The penetration mechanism and influencing factors of iontophoresis,and the study on the combination of iontophoresis with hydrogel,microneedles or nano-carrier were reviewed in this paper.