舒肝宁联合多烯磷脂酰胆碱治疗肝硬化的临床效果

Clinical effect of Shuganning combined with polyene phosphatidylcholine in the treatment of liver cirrhosis

目的探讨舒肝宁联合多烯磷脂酰胆碱治疗肝硬化的临床效果,以为临床治疗该病提供参考。方法选取2020年1月至2022年9月我院收治的198例肝硬化患者作为研究对象,随机将其分为常规组和观察组,各99例。常规组给予多烯磷脂酰胆碱治疗,观察组在常规组基础上给予舒肝宁治疗。比较两组的临床疗效、肝功能指标、凝血功能指标、炎症指标、血常规指标及不良反应发生情况。结果观察组的治疗总有效率高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)及总胆红素(TBIL)水平低于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于常规组,纤维蛋白原(FIB)水平高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的C-反应蛋白(CRP)水平低于常规组,白细胞计数(WBC)、中性粒细胞计数(NEUT)及血小板计数(PLT)高于常规组,差异具有统计学意义(P<0.05)。观察组治疗期间的不良反应总发生率低于常规组,差异具有统计学意义(P<0.05)。结论舒肝宁联合多烯磷脂酰胆碱治疗肝硬化的效果较好,可改善患者肝功能、凝血功能,减少药物不良反应,值得临床应用和推广。

Objective To investigate the clinical effect of Shuganning combined with polyene phosphatidylcholine in the treatment of liver cirrhosis,so as to provide reference for clinical treatment of this disease.Methods A total of 198 patients with liver cirrhosis admitted in our hospital from January 2020 to September 2022 were selected as the research objects and randomly divided into conventional group and observation group,with 99 cases in each group.The conventional group was treated with polyene phosphatidylcholine,while the observation group was treated with Shuganning on the basis of the conventional group.The clinical efficacy,liver function indicators,coagulation function indicators,inflammation indicators,blood routine indicators and occurrence of adverse reactions of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TBIL)in the observation group were lower than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)of the observation group were shorter than those of the conventional group,the level of fibrinogen(FIB)was higher than that of the conventional group,and the differences were statistically significant(P<0.05).After treatment,the level of C-reactive protein(CRP)in the observation group was lower than that in the conventional group,while the white blood cell count(WBC),neutrophil count(NEUT)and platelet count(PLT)were higher than those in the conventional group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions during treatment in the observation group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Shuganning combined with polyene phosphatidylcholine is effective in the treatment of liver cirrhosis,it can improve liver function and coagulation function,and reduce adverse drug reactions,which is worthy of clinical application and promotion.