血府逐瘀胶囊联合阿奇霉素序贯疗法治疗慢性盆腔炎的效果及对抗炎-促炎因子表达、TGF-β_(1)、GM-CSF水平的影响

Effect of Xuefu Zhuyu capsules combined with azithromycin sequential therapy on chronic pelvic inflammatory disease and its influences on anti-inflammatory-proinflammatory factors expression,TGF-β_(1)and GM-CSF levels

目的探讨血府逐瘀胶囊联合阿奇霉素序贯疗法治疗慢性盆腔炎(CPID)的效果及对抗炎-促炎因子表达、转化生长因子-β_(1)(TGF-β_(1))、粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平的影响。方法选取2018年9月至2021年3月收治的106例CPID患者为研究对象,以随机数字表法将其分为对照组与观察组,各53例。对照组采用阿奇霉素序贯疗法,观察组在对照组基础上加用血府逐瘀胶囊。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及白细胞介素-17(IL-17)水平比较,差异无统计学意义(P>0.05);治疗后,观察组的IL-6及IL-17水平低于对照组,IL-10水平高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的TGF-β_(1)、GM-CSF水平比较,差异无统计学意义(P>0.05);治疗后,观察组的TGF-β_(1)、GM-CSF水平低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的生理职能、精神健康、躯体疼痛及总体健康评分比较,差异无统计学意义(P>0.05);治疗后,观察组的生理职能、精神健康、躯体疼痛及总体健康评分高于对照组,差异具有统计学意义(P<0.05)。结论血府逐瘀胶囊联合阿奇霉素序贯疗法治疗CPID效果满意,可调节抗炎-促炎因子表达,改善TGF-β_(1)、GM-CSF水平,提高患者的生活质量,值得临床推广应用。

Objective To explore the effect of Xuefu Zhuyu capsules combined with azithromycin sequential therapy on chronic pelvic inflammatory disease(CPID)and its influences on anti-inflammatory-proinflammatory factors expression,transforming growth factor-β_(1)(TGF-β_(1))and granulocyte-macrophage colony-stimulating factor(GM-CSF)levels.Methods A total of 106 patients with CPID admitted from September 2018 to March 2021 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 53 cases in each group.The control group was given azithromycin sequential therapy,and the observation group was treated with Xuefu Zhuyu capsules on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of interleukin-6(IL-6),interleukin-10(IL-10)and interleukin-17(IL-17)between the two groups(P>0.05);after treatment,the levels of IL-6 and IL-17 in the observation group were lower than those in the control group,the level of IL-10 was higher than that in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of TGF-β_(1)and GM-CSF between the two groups(P>0.05);after treatment,the levels of TGF-β_(1)and GM-CSF in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of role-physical,mental health,bodily pain and general health between the two groups(P>0.05);after treatment,the scores of role-physical,mental health,bodily pain and general health in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Xuefu Zhuyu capsules combined with azithromycin sequential therapy in the treatment of CPID has satisfactory effect,it can regulate the expression of anti-inflammatory-proinflammatory factors,improve the levels of TGF-β_(1)and GM-CSF,and improve the quality of life of patients,which is worthy of clinical promotion and application.