布地奈德混悬液雾化吸入在慢性阻塞性肺疾病急性加重期患者中的应用

Application of aerosol inhalation of budesonide suspension in acute exacerbation of chronic obstructive pulmonary disease

目的探讨不同剂量布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效.方法选取我院2020年6月至2021年12月收治的150例AECOPD患者,采用随机数表法分为高剂量组和低剂量组各75例,高剂量组和低剂量组分别按6mg/d剂量和3mg/d剂量布地奈德雾化吸入,对比用药前后两组CAT评分、肺功能、血气指标、总有效率及不良反应率的差别.结果用药后,高剂量组CAT评分为8.09分,低于低剂量组的9.71分(P<0.05);高剂量组肺功能指标FEV1为1.80L、FEV_(1)/FVC为66.32%、FEV_(1)%预计值为62.77,均高于低剂量组的1.64L、58.43%、57.99(均P<0.05);高剂量组血气指标PO2为82􀆰45mmHg,高于低剂量组的73􀆰62mmHg(P<0.05);PCO_(2)为58.03mmHg,低于低剂量组的63.95mmHg(P<0.05);高剂量组总有效率96.00%,高于低剂量组81.33%(P<0.05);高剂量组不良反应发生率(30.67%)与低剂量组(28.00%)比较的差异无统计学意义(P>0.05).结论高剂量布地奈德雾化吸入更有效改善AECOPD患者肺功能及缺氧状态,疗效更显著,不良反应率增加不明显.

Objective To investigate the clinical effect of budesonide atomized inhalation suspension with different doses in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 150 patients with AECOPD diagnosed and treated in our hospital from June 2020 to December 2021 were randomly divided into high dose group(75 cases)and low dose group(75 cases).The high dose group and the low dose group were given respectively with the 6 mg daily dose and the 3 mg daily dose of budesonide aerosol inhalation.The changes of the CAT scores,lung function,blood gas indicators,total treatment efective rates and adverse reaction rate were compared between the two groups before and after treatment.Results After treatment,the CAT score of the high dose group(8.09)was lower than that of the low dose group(9.71),there was significant difference(P<0.05)between them;the lung function indexes FEV_(1),FEV_(1)/FVC and FEV_(1)%predicted of the high dose group(1.80 L,66.32% and 62.77)were respectively higher than those of the low dose group(1.64 L,58.43% and 57.99),and there were significant differences(P<0.05)between them;the blood gas index PO_(2) of the high:dose group(82.45 mm Hg)was higher than that of the low dose group(73.62 mm Hg),and the PCO_(2) of the high dose group(58.03 mm Hg)was lower than that of the low dose group(63.95 mm Hg),there were significant differences(P<0.05)be-tween them;the total effective rate of the high dose group(96.00%)was higher than that of the low dose group(81.33%),and there was significant difference(P<0.05)between them;there was no significant difference(P>0.05)between the ad-verse reaction rate of the high dose group(30.67%)and that of the low dose group(28.00%)。Conclusion High dose of budesonide atomized inhalation suspension can effectively improve lung function and hypoxia in AECOPD patients,which has significant clinical efects,while the increase of adverse reaction rate is not obvious.