手机使用情况与男性精液质量和性激素的关联

Associations of mobile phone use with male semen quality and sex hormones

[背景]实验研究表明手机发射的射频电磁波具有降低精液质量和改变性激素等生殖毒性,但有关手机使用情况与男性精液质量的流行病学研究结果并不一致。此外,很少有流行病学研究探讨手机使用情况对性激素的影响。[目的]探讨手机使用情况与男性精液质量和性激素的关联。[方法]以2018年12月—2020年1月期间来武汉市某医院生殖医学中心寻求不孕不育检查夫妇中的2045名男性为研究对象,通过问卷调查获得研究对象的手机使用情况,其中1232名男性纳入精液质量分析,1694名男性纳入性激素分析。采用多变量线性回归和logistic回归模型分析手机使用情况与男性精液质量和性激素之间的关联。[结果]校正混杂因素后,发现手机使用情况与精子前向运动力、精子总活力、精子浓度和精子总数以及血清促黄体生成素关联均无统计学意义(P>0.05)。但发现血清总睾酮随着每日手机使用时长的增加呈下降趋势(P趋势=0.08)。与每日手机使用时长0~2 h组相比,使用时长2.1~5 h、5.1~8 h和>8 h的男性血清总睾酮浓度分别平均下降了6.29%(95%CI:0.40%~11.84%)、6.01%(95%CI:0.60%~12.19%)和7.87%(95%CI:0.40%~14.79%)。[结论]本研究未发现手机使用情况与男性精液质量和血清促黄体生成素相关,但随着每日手机使用时长的增加,男性血清总睾酮呈现出潜在降低的趋势。

[Background] Experimental studies have shown that radiofrequency electromagnetic waves emitted by mobile phones can cause adverse effects on male reproductive health, including decreased semen quality and altered sex hormones. However, the results of epidemiological studies on the relationship between mobile phone use and male semen quality are inconsistent. Furthermore, there are few epidemiological studies on the association of mobile phone use with sex hormones.[Objective] To explore the associations of mobile phone use with male semen quality and sex hormones.[Methods] A total of 2 045 men visited the reproductive medicine center of a hospital in Wuhan and ordered infertility examination were recruited from December 2018 to January 2020. Information on mobile phone use was obtained using a questionnaire. Among them, 1 232 and 1 694 men were eligible for semen quality analyses and sex hormone analyses, respectively. Multiple linear and logistic regression models were used to analyze the associations of mobile phone use with male semen quality and sex hormones.[Results] After adjusting for potential confounders, there was no statistically significant associations of mobile phone use with sperm progressive motility, sperm total motility, sperm concentration, sperm count, or serum luteinizing hormone(P > 0.05). However, serum total testosterone showed a declined tendency with increasing daily duration of mobile phone use(Ptrend=0.08). Compared with men with daily mobile phone use of 0-2 h, men with daily mobile phone use of 2.1-5, 5.1-8, and > 8 h showed decreased serum total testosterone concentrations by 6.29%(95%CI: 0.40%-11.84%), 6.01%(95%CI: 0.60%-12.19%), and 7.87%(95%CI: 0.40%-14.79%), respectively.[Conclusion] Mobile phone use is not associated with male semen quality and serum luteinizing hormone, but increasing daily duration of mobile phone use is potentially associated with a tendency to lower male serum total testosterone.