CRRT联合rhBNP综合治疗对急性失代偿性心力衰竭高龄患者肾功能及28d全因死亡率的影响

Effect of Combined Treatment of CRRT and rhBNP on Renal Function and 28-day All-cause Mortality in Elderly Patients with Acute Decompensated Heart Failure

目的:分析CRRT联合rhBNP综合治疗对急性失代偿性心力衰竭高龄患者肾功能及28d全因死亡率。方法:选取2018年6月—2020年6月本院收治的急性失代偿性心力衰竭高龄患者128例作为研究对象,采取随机抽签分组方式分为对照组和观察组,每组64例。观察组实施CRRT联合rhBNP综合治疗,对照组实施CRRT治疗,比较两组心功能指标、肾功能指标、疾病控制率、生存率和生存时间。结果:观察组各时间LVEF、LVESV、LVEDV指标优于对照组(P<0.05);观察组各时间24h尿量、尿素氮、肌酐改善情况优于对照组(P<0.05);观察组治疗后1周、2周、4周的疾病控制率低于对照组(P<0.05);观察组28d后生存率高于对照组,生存时间长于对照组(P<0.05)。结论:通过对急性失代偿性心力衰竭高龄患者采取CRRT联合rhBNP综合治疗,能显著改善患者肾功能,提高生存率。

Objective:To analyze the effects of CRRT combined with rhBNP treatment on renal function and 28-day allcause mortality in elderly patients with acute decompensated heart failure.Methods:A total of 128 elderly patients with acute decompensated heart failure admitted to our hospital from June 2018 to June 2020 were selected as subjects.They were randomly divided into control group and observation group,with 64 cases in each group.The observation group was treated with CRRT combined with rhBNP,and the control group was treated with CRRT.The cardiac function indexes,renal function indexes,disease control rate,survival rate and survival time were compared between the two groups.Results:The LVEF,LVESV and LVEDV at each time in the observation group were better than those in the control group(P<0.05).The improvement of 24 h urine volume,urea nitrogen and creatinine in the observation group was better than that in the control group(P<0.05).The disease control rates at 1,2 and 4 weeks after treatment in the observation group were lower than those in the control group(P<0.05).The survival rate of the observation group after 28 d was higher than that of the control group,and the survival time was longer than that of the control group(P<0.05).Conclusion:The combined treatment of CRRT and rhBNP in elderly patients with acute decompensated heart failure can significantly improve the renal function of patients and increasethe survival rate.